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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The effect of modafinil on the rat dopamine transporter and dopamine receptors D1–D3 paralleling cognitive enhancement in the radial arm maze
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, August 2015
|
| DOI | 10.3389/fnbeh.2015.00215 |
| Pubmed ID | |
| Authors |
Yasemin Karabacak, Sunetra Sase, Yogesh D. Aher, Ajinkya Sase, Sivaprakasam R. Saroja, Ana Cicvaric, Harald Höger, Michael Berger, Vasiliy Bakulev, Harald H. Sitte, Johann Leban, Francisco J. Monje, Gert Lubec |
| Abstract |
A series of drugs have been reported to increase memory performance modulating the dopaminergic system and herein modafinil was tested for its working memory (WM) enhancing properties. Reuptake inhibition of dopamine, serotonin (SERT) and norepinephrine (NET) by modafinil was tested. Sixty male Sprague-Dawley rats were divided into six groups (modafinil-treated 1-5-10 mg/kg body weight, trained and untrained and vehicle treated trained and untrained rats; daily injected intraperitoneally for a period of 10 days) and tested in a radial arm maze (RAM), a paradigm for testing spatial WM. Hippocampi were taken 6 h following the last day of training and complexes containing the unphosphorylated or phosphorylated dopamine transporter (DAT-CC and pDAT-CC) and complexes containing the D1-3 dopamine receptor subunits (D1-D3-CC) were determined. Modafinil was binding to the DAT but insignificantly to SERT or NET and dopamine reuptake was blocked specifically (IC50 = 11.11 μM; SERT 1547 μM; NET 182 μM). From day 8 (day 9 for 1 mg/kg body weight) modafinil was decreasing WM errors (WMEs) in the RAM significantly and remarkably at all doses tested as compared to the vehicle controls. WMEs were linked to the D2R-CC and the pDAT-CC. pDAT and D1-D3-CC levels were modulated significantly and modafinil was shown to enhance spatial WM in the rat in a well-documented paradigm at all the three doses and dopamine reuptake inhibition with subsequent modulation of D1-3-CC is proposed as a possible mechanism of action. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 29% |
| Researcher | 9 | 16% |
| Student > Master | 6 | 11% |
| Student > Doctoral Student | 3 | 5% |
| Other | 3 | 5% |
| Other | 8 | 15% |
| Unknown | 10 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 20% |
| Agricultural and Biological Sciences | 9 | 16% |
| Psychology | 6 | 11% |
| Medicine and Dentistry | 5 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Other | 9 | 16% |
| Unknown | 11 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2015.
All research outputs
#15,293,077
of 22,824,164 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,197
of 3,168 outputs
Outputs of similar age
#155,432
of 266,176 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#71
of 86 outputs
Altmetric has tracked 22,824,164 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,168 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,176 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.