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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, September 2015
|
| DOI | 10.3389/fnbeh.2015.00235 |
| Pubmed ID | |
| Authors |
Martin Häring, Vanessa Enk, Alejandro Aparisi Rey, Sebastian Loch, Inigo Ruiz de Azua, Tillmann Weber, Dusan Bartsch, Krisztina Monory, Beat Lutz |
| Abstract |
The endocannabinoid (eCB) system possesses neuromodulatory functions by influencing the release of various neurotransmitters, including γ-aminobutyric acid (GABA) and glutamate. A functional interaction between eCBs and the serotonergic system has already been suggested. Previously, we showed that cannabinoid type-1 (CB1) receptor mRNA and protein are localized in serotonergic neurons of the raphe nuclei, implying that the eCB system can modulate serotonergic functions. In order to substantiate the physiological role of the CB1 receptor in serotonergic neurons of the raphe nuclei, we generated serotonergic 5-hydroxytryptamine (5-HT) neuron-specific CB 1 receptor-deficient mice, using the Cre/loxP system with a tamoxifen-inducible Cre recombinase under the control of the regulatory sequences of the tryptophan hydroxylase 2 gene (TPH2-CreER (T2)), thus, restricting the recombination to 5-HT neurons of the central nervous system (CNS). Applying several different behavioral paradigms, we revealed that mice lacking the CB1 receptor in serotonergic neurons are more anxious and less sociable than control littermates. Thus, we were able to show that functional CB1 receptor signaling in central serotonergic neurons modulates distinct behaviors in mice. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 33% |
| Canada | 1 | 17% |
| United States | 1 | 17% |
| Australia | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 88 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 16% |
| Researcher | 11 | 12% |
| Student > Master | 11 | 12% |
| Student > Doctoral Student | 8 | 9% |
| Student > Bachelor | 6 | 7% |
| Other | 15 | 17% |
| Unknown | 25 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 15 | 17% |
| Biochemistry, Genetics and Molecular Biology | 10 | 11% |
| Medicine and Dentistry | 8 | 9% |
| Agricultural and Biological Sciences | 7 | 8% |
| Psychology | 6 | 7% |
| Other | 13 | 14% |
| Unknown | 31 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2018.
All research outputs
#7,057,116
of 25,402,528 outputs
Outputs from Frontiers in Behavioral Neuroscience
#1,058
of 3,465 outputs
Outputs of similar age
#75,847
of 277,012 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#28
of 86 outputs
Altmetric has tracked 25,402,528 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 3,465 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,012 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.