You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dissecting Alzheimer disease in Down syndrome using mouse models
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, October 2015
|
| DOI | 10.3389/fnbeh.2015.00268 |
| Pubmed ID | |
| Authors |
Xun Yu Choong, Justin L. Tosh, Laura J. Pulford, Elizabeth M. C. Fisher |
| Abstract |
Down syndrome (DS) is a common genetic condition caused by the presence of three copies of chromosome 21 (trisomy 21). This greatly increases the risk of Alzheimer disease (AD), but although virtually all people with DS have AD neuropathology by 40 years of age, not all develop dementia. To dissect the genetic contribution of trisomy 21 to DS phenotypes including those relevant to AD, a range of DS mouse models has been generated which are trisomic for chromosome segments syntenic to human chromosome 21. Here, we consider key characteristics of human AD in DS (AD-DS), and our current state of knowledge on related phenotypes in AD and DS mouse models. We go on to review important features needed in future models of AD-DS, to understand this type of dementia and so highlight pathogenic mechanisms relevant to all populations at risk of AD. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| United States | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 76 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 19% |
| Student > Master | 15 | 19% |
| Student > Bachelor | 10 | 13% |
| Researcher | 10 | 13% |
| Student > Postgraduate | 4 | 5% |
| Other | 5 | 6% |
| Unknown | 21 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 24% |
| Agricultural and Biological Sciences | 15 | 19% |
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Medicine and Dentistry | 8 | 10% |
| Psychology | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 22 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2015.
All research outputs
#14,239,950
of 22,830,751 outputs
Outputs from Frontiers in Behavioral Neuroscience
#1,895
of 3,170 outputs
Outputs of similar age
#144,638
of 279,229 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#50
of 88 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,170 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,229 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.