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The Involvement of Genes in Adolescent Depression: A Systematic Review

Overview of attention for article published in Frontiers in Behavioral Neuroscience, December 2015
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  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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30 Dimensions

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109 Mendeley
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Title
The Involvement of Genes in Adolescent Depression: A Systematic Review
Published in
Frontiers in Behavioral Neuroscience, December 2015
DOI 10.3389/fnbeh.2015.00329
Pubmed ID
Authors

Liangwei Xia, Shuqiao Yao

Abstract

Numerous studies have reported on the roles of genetic factors in the development of depression in adolescents and young adults. However, there are few systematic reviews that update our understanding of adolescent depression with the biological findings identifying the roles of gene expression and/or polymorphism(s). This review systematically summarized the findings that clearly identified the contribution of a gene to the risk of depression in adolescents between the ages of 10 and 19 years old and young adults between the ages of 20 and 25 years old. Data were obtained through searching PubMed, Embase, and Web of Science. A total of 47 studies on early adolescence and three studies on young adults were included in the current review. Most articles studied genes in the serotonergic system (n = 26), dopaminergic system (n = 3), and the Brain-derived neurotropic factor (BDNF) gene (n = 12). 92.3% of studies (24/26) identified positive associations of 5-HTTLPR polymorphism with depressive illness or depressive symptoms. 83.3% of studies (10/12) found positive association between BDNF Val66Met genotype and adolescent depressive symptoms. More studies should be conducted on the 18 genes reported in a few studies to clarify their roles in the risk for adolescent depression.

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X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 108 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 15%
Student > Bachelor 14 13%
Student > Ph. D. Student 13 12%
Researcher 9 8%
Student > Doctoral Student 7 6%
Other 18 17%
Unknown 32 29%
Readers by discipline Count As %
Medicine and Dentistry 22 20%
Psychology 20 18%
Social Sciences 8 7%
Neuroscience 8 7%
Biochemistry, Genetics and Molecular Biology 7 6%
Other 12 11%
Unknown 32 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2016.
All research outputs
#7,468,612
of 22,832,057 outputs
Outputs from Frontiers in Behavioral Neuroscience
#1,273
of 3,171 outputs
Outputs of similar age
#121,327
of 389,455 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#34
of 84 outputs
Altmetric has tracked 22,832,057 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,171 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 389,455 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.