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Distinct Types of Feeding Related Neurons in Mouse Hypothalamus

Overview of attention for article published in Frontiers in Behavioral Neuroscience, May 2016
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Title
Distinct Types of Feeding Related Neurons in Mouse Hypothalamus
Published in
Frontiers in Behavioral Neuroscience, May 2016
DOI 10.3389/fnbeh.2016.00091
Pubmed ID
Authors

Yan Tang, Diego Benusiglio, Valery Grinevich, Longnian Lin

Abstract

The last two decades of research provided evidence for a substantial heterogeneity among feeding-related neurons (FRNs) in the hypothalamus. However, it remains unclear how FRNs differ in their firing patterns during food intake. Here, we investigated the relationship between the activity of neurons in mouse hypothalamus and their feeding behavior. Using tetrode-based in vivo recording technique, we identified various firing patterns of hypothalamic FRNs, which, after the initiation of food intake, can be sorted into four types: sharp increase (type I), slow increase (type II), sharp decrease (type III), and sustained decrease (type IV) of firing rates. The feeding-related firing response of FRNs was rigidly related to the duration of food intake and, to a less extent, associated with the type of food. The majority of these FRNs responded to glucose and leptin and exhibited electrophysiological characteristics of putative GABAergic neurons. In conclusion, our study demonstrated the diversity of neurons in the complex hypothalamic network coordinating food intake.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 40%
Researcher 4 16%
Student > Bachelor 2 8%
Student > Master 2 8%
Student > Doctoral Student 1 4%
Other 5 20%
Unknown 1 4%
Readers by discipline Count As %
Neuroscience 13 52%
Agricultural and Biological Sciences 6 24%
Medicine and Dentistry 2 8%
Physics and Astronomy 1 4%
Unknown 3 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2017.
All research outputs
#14,850,641
of 22,870,727 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,044
of 3,184 outputs
Outputs of similar age
#198,463
of 334,246 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#47
of 77 outputs
Altmetric has tracked 22,870,727 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,184 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,246 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.