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Attention Score in Context
| Title |
Prenatal Stress, Fearfulness, and the Epigenome: Exploratory Analysis of Sex Differences in DNA Methylation of the Glucocorticoid Receptor Gene
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, July 2016
|
| DOI | 10.3389/fnbeh.2016.00147 |
| Pubmed ID | |
| Authors |
Brendan D. Ostlund, Elisabeth Conradt, Sheila E. Crowell, Audrey R. Tyrka, Carmen J. Marsit, Barry M. Lester |
| Abstract |
Exposure to stress in utero is a risk factor for the development of problem behavior in the offspring, though precise pathways are unknown. We examined whether DNA methylation of the glucocorticoid receptor gene, NR3C1, was associated with experiences of stress by an expectant mother and fearfulness in her infant. Mothers reported on prenatal stress and infant temperament when infants were 5 months old (n = 68). Buccal cells for methylation analysis were collected from each infant. Prenatal stress was not related to infant fearfulness or NR3C1 methylation in the sample as a whole. Exploratory sex-specific analysis revealed a trend-level association between prenatal stress and increased methylation of NR3C1 exon 1F for female, but not male, infants. In addition, increased methylation was significantly associated with greater fearfulness for females. Results suggest an experience-dependent pathway to fearfulness for female infants via epigenetic modification of the glucocorticoid receptor gene. Future studies should examine prenatal stress in a comprehensive fashion while considering sex differences in epigenetic processes underlying infant temperament. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 25% |
| United States | 1 | 25% |
| Switzerland | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 151 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 30 | 20% |
| Student > Ph. D. Student | 26 | 17% |
| Student > Bachelor | 17 | 11% |
| Researcher | 14 | 9% |
| Student > Doctoral Student | 13 | 9% |
| Other | 30 | 20% |
| Unknown | 21 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 38 | 25% |
| Biochemistry, Genetics and Molecular Biology | 28 | 19% |
| Agricultural and Biological Sciences | 20 | 13% |
| Medicine and Dentistry | 15 | 10% |
| Neuroscience | 11 | 7% |
| Other | 9 | 6% |
| Unknown | 30 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2016.
All research outputs
#14,268,160
of 22,880,230 outputs
Outputs from Frontiers in Behavioral Neuroscience
#1,899
of 3,187 outputs
Outputs of similar age
#205,045
of 354,439 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#35
of 67 outputs
Altmetric has tracked 22,880,230 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,187 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,439 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.