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Attention Score in Context
| Title |
Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, October 2016
|
| DOI | 10.3389/fnbeh.2016.00196 |
| Pubmed ID | |
| Authors |
Susan R. Berkowicz, Travis J. Featherby, James C. Whisstock, Phillip I. Bird |
| Abstract |
Background:Brinps 1-3, and Astrotactins (Astn) 1 and 2, are members of the Membrane Attack Complex/Perforin (MACPF) superfamily that are predominantly expressed in the mammalian brain during development. Genetic variation at the human BRINP2/ASTN1 and BRINP1/ASTN2 loci has been implicated in neurodevelopmental disorders. We, and others, have previously shown that Brinp1(-/-) mice exhibit behavior reminiscent of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Method: We created Brinp2(-/-) mice and Brinp3(-/-) mice via the Cre-mediated LoxP system to investigate the effect of gene deletion on anatomy and behavior. Additionally, Brinp2(-/-)Brinp3(-/-) double knock-out mice were generated by interbreeding Brinp2(-/-) and Brinp3(-/-) mice. Genomic validation was carried out for each knock-out line, followed by histological, weight and behavioral examination. Brinp1(-/-)Brinp2(-/-)Brinp3(-/-) triple knock-out mice were also generated by crossing Brinp2/3 double knock-out mice with previously generated Brinp1(-/-) mice, and examined by weight and histological analysis. Results:Brinp2(-/-) and Brinp3(-/-) mice differ in their behavior: Brinp2(-/-) mice are hyperactive, whereas Brinp3(-/-) mice exhibit marked changes in anxiety-response on the elevated plus maze. Brinp3(-/-) mice also show evidence of altered sociability. Both Brinp2(-/-) and Brinp3(-/-) mice have normal short-term memory, olfactory responses, pre-pulse inhibition, and motor learning. The double knock-out mice show behaviors of Brinp2(-/-) and Brinp3(-/-) mice, without evidence of new or exacerbated phenotypes. Conclusion:Brinp3 is important in moderation of anxiety, with potential relevance to anxiety disorders. Brinp2 dysfunction resulting in hyperactivity may be relevant to the association of ADHD with chromosome locus 1q25.2. Brinp2(-/-) and Brinp3(-/-) genes do not compensate in the mammalian brain and likely have distinct molecular or cell-type specific functions. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 13% |
| Student > Master | 5 | 9% |
| Student > Postgraduate | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Professor | 3 | 6% |
| Other | 10 | 19% |
| Unknown | 21 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 13% |
| Psychology | 7 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Agricultural and Biological Sciences | 3 | 6% |
| Medicine and Dentistry | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 24 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2016.
All research outputs
#15,339,935
of 22,896,955 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,208
of 3,190 outputs
Outputs of similar age
#196,298
of 313,870 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#44
of 60 outputs
Altmetric has tracked 22,896,955 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,190 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,870 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.