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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, October 2016
|
| DOI | 10.3389/fnbeh.2016.00204 |
| Pubmed ID | |
| Authors |
Nicole El Massioui, Charlotte Lamirault, Sara Yagüe, Najia Adjeroud, Daniel Garces, Alexis Maillard, Lucille Tallot, Libo Yu-Taeger, Olaf Riess, Philippe Allain, Huu Phuc Nguyen, Stephan von Hörsten, Valérie Doyère |
| Abstract |
Cognitive deficits associated with Huntington disease (HD) are generally dominated by executive function disorders often associated with disinhibition and impulsivity/compulsivity. Few studies have directly examined symptoms and consequences of behavioral disinhibition in HD and its relation with decision-making. To assess the different forms of impulsivity in a transgenic model of HD (tgHD rats), two tasks assessing cognitive/choice impulsivity were used: risky decision-making with a rat gambling task (RGT) and intertemporal choices with a delay discounting task (DD). To assess waiting or action impulsivity the differential reinforcement of low rate of responding task (DRL) was used. In parallel, the volume as well as cellular activity of the amygdala was analyzed. In contrast to WT rats, 15 months old tgHD rats exhibited a poor efficiency in the RGT task with difficulties to choose advantageous options, a steep DD curve as delays increased in the DD task and a high rate of premature and bursts responses in the DRL task. tgHD rats also demonstrated a concomitant and correlated presence of both action and cognitive/choice impulsivity in contrast to wild type (WT) animals. Moreover, a reduced volume associated with an increased basal cellular activity of the central nucleus of amygdala indicated a dysfunctional amygdala in tgHD rats, which could underlie inhibitory dyscontrol. In conclusion, tgHD rats are a good model for impulsivity disorder that could be used more widely to identify potential pharmacotherapies to treat these invasive symptoms in HD. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iraq | 1 | 20% |
| United States | 1 | 20% |
| Italy | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 1 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 4% |
| France | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 45 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 29% |
| Researcher | 10 | 20% |
| Student > Master | 5 | 10% |
| Student > Postgraduate | 3 | 6% |
| Student > Bachelor | 3 | 6% |
| Other | 6 | 12% |
| Unknown | 8 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 29% |
| Psychology | 10 | 20% |
| Agricultural and Biological Sciences | 5 | 10% |
| Medicine and Dentistry | 3 | 6% |
| Business, Management and Accounting | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 11 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2016.
All research outputs
#13,477,523
of 23,262,131 outputs
Outputs from Frontiers in Behavioral Neuroscience
#1,557
of 3,241 outputs
Outputs of similar age
#161,955
of 315,270 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#31
of 60 outputs
Altmetric has tracked 23,262,131 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,241 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,270 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.