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Attention Score in Context
| Title |
Validity of Quinpirole Sensitization Rat Model of OCD: Linking Evidence from Animal and Clinical Studies
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, October 2016
|
| DOI | 10.3389/fnbeh.2016.00209 |
| Pubmed ID | |
| Authors |
Ales Stuchlik, Dominika Radostová, Hana Hatalova, Karel Vales, Tereza Nekovarova, Jana Koprivova, Jan Svoboda, Jiri Horacek |
| Abstract |
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with 1-3% prevalence. OCD is characterized by recurrent thoughts (obsessions) and repetitive behaviors (compulsions). The pathophysiology of OCD remains unclear, stressing the importance of pre-clinical studies. The aim of this article is to critically review a proposed animal model of OCD that is characterized by the induction of compulsive checking and behavioral sensitization to the D2/D3 dopamine agonist quinpirole. Changes in this model have been reported at the level of brain structures, neurotransmitter systems and other neurophysiological aspects. In this review, we consider these alterations in relation to the clinical manifestations in OCD, with the aim to discuss and evaluate axes of validity of this model. Our analysis shows that some axes of validity of quinpirole sensitization model (QSM) are strongly supported by clinical findings, such as behavioral phenomenology or roles of brain structures. Evidence on predictive validity is contradictory and ambiguous. It is concluded that this model is useful in the context of searching for the underlying pathophysiological basis of the disorder because of the relatively strong biological similarities with OCD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 19% |
| Student > Ph. D. Student | 6 | 13% |
| Researcher | 4 | 8% |
| Student > Master | 4 | 8% |
| Unspecified | 3 | 6% |
| Other | 9 | 19% |
| Unknown | 13 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 25% |
| Psychology | 7 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Unspecified | 3 | 6% |
| Agricultural and Biological Sciences | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 16 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2016.
All research outputs
#18,478,448
of 22,896,955 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,614
of 3,190 outputs
Outputs of similar age
#237,376
of 314,045 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#48
of 60 outputs
Altmetric has tracked 22,896,955 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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