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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Working Memory after Traumatic Brain Injury: The Neural Basis of Improved Performance with Methylphenidate
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, April 2017
|
| DOI | 10.3389/fnbeh.2017.00058 |
| Pubmed ID | |
| Authors |
Anne E. Manktelow, David K. Menon, Barbara J. Sahakian, Emmanuel A. Stamatakis |
| Abstract |
Traumatic brain injury (TBI) often results in cognitive impairments for patients. The aim of this proof of concept study was to establish the nature of abnormalities, in terms of activity and connectivity, in the working memory network of TBI patients and how these relate to compromised behavioral outcomes. Further, this study examined the neural correlates of working memory improvement following the administration of methylphenidate. We report behavioral, functional and structural MRI data from a group of 15 Healthy Controls (HC) and a group of 15 TBI patients, acquired during the execution of the N-back task. The patients were studied on two occasions after the administration of either placebo or 30 mg of methylphenidate. Between group tests revealed a significant difference in performance when HCs were compared to TBI patients on placebo [F(1, 28) = 4.426, p < 0.05, η p(2) = 0.136]. This difference disappeared when the patients took methylphenidate [F(1, 28) = 3.665, p = 0.66]. Patients in the middle range of baseline performance demonstrated the most benefit from methylphenidate. Changes in the TBI patient activation levels in the Left Cerebellum significantly and positively correlated with changes in performance (r = 0.509, df = 13, p = 0.05). Whole-brain connectivity analysis using the Left Cerebellum as a seed revealed widespread negative interactions between the Left Cerebellum and parietal and frontal cortices as well as subcortical areas. Neither the TBI group on methylphenidate nor the HC group demonstrated any significant negative interactions. Our findings indicate that (a) TBI significantly reduces the levels of activation and connectivity strength between key areas of the working memory network and (b) Methylphenidate improves the cognitive outcomes on a working memory task. Therefore, we conclude that methylphenidate may render the working memory network in a TBI group more consistent with that of an intact working memory network. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 8 | 31% |
| United States | 5 | 19% |
| Ireland | 2 | 8% |
| Japan | 1 | 4% |
| Australia | 1 | 4% |
| Switzerland | 1 | 4% |
| Czechia | 1 | 4% |
| Netherlands | 1 | 4% |
| Unknown | 6 | 23% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 65% |
| Scientists | 5 | 19% |
| Practitioners (doctors, other healthcare professionals) | 4 | 15% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 91 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 15% |
| Student > Ph. D. Student | 12 | 13% |
| Student > Bachelor | 10 | 11% |
| Researcher | 10 | 11% |
| Student > Doctoral Student | 8 | 9% |
| Other | 11 | 12% |
| Unknown | 26 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 20 | 22% |
| Neuroscience | 19 | 21% |
| Nursing and Health Professions | 5 | 5% |
| Medicine and Dentistry | 5 | 5% |
| Agricultural and Biological Sciences | 3 | 3% |
| Other | 9 | 10% |
| Unknown | 30 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2017.
All research outputs
#2,240,972
of 24,378,020 outputs
Outputs from Frontiers in Behavioral Neuroscience
#376
of 3,356 outputs
Outputs of similar age
#42,171
of 313,472 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#7
of 67 outputs
Altmetric has tracked 24,378,020 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,356 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,472 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.