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Repeated Low Intensity Blast Exposure Is Associated with Damaged Endothelial Glycocalyx and Downstream Behavioral Deficits

Overview of attention for article published in Frontiers in Behavioral Neuroscience, June 2017
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Title
Repeated Low Intensity Blast Exposure Is Associated with Damaged Endothelial Glycocalyx and Downstream Behavioral Deficits
Published in
Frontiers in Behavioral Neuroscience, June 2017
DOI 10.3389/fnbeh.2017.00104
Pubmed ID
Authors

Aaron A Hall, Mirian I Mendoza, Hanbing Zhou, Michael Shaughness, Eric Maudlin-Jeronimo, Richard M McCarron, Stephen T Ahlers

Abstract

Current clinical research into mild traumatic brain injury (mTBI) has focused on white matter changes as identified by advanced MRI based imaging techniques. However, perivascular tau accumulation in the brains of individuals diagnosed with mTBI suggests that the vasculature plays a key role in the pathology. This study used a rat model to examine whether the endothelial glycocalyx, a layer of the vasculature responsible for sensing luminal shear forces, is damaged by exposure to repeated low intensity blast, and whether this layer is associated with observed behavioral deficits. The blast exposure used consisted of 12, 40 kPa blast exposures conducted with a minimum of 24 h between blasts. We found that repeated blast exposure reduced glycocalyx length and density in various brain regions indicating damage. This blast exposure paradigm was associated with a mild performance decrement in the Morris water maze (MWM) which assesses learning and memory. Administration of hyaluronidase, an enzyme that binds to and degrades hyaluronan (a major structural component of the glycocalyx) prior to blast exposure reduced the observed behavioral deficits and induced a thickening of the glycocalyx layer. Taken together these findings demonstrate that the endothelial glycocalyx degradation following repeated blast is associated with behavioral decrements which can be prevented by treatment with hyaluronidase.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 15%
Student > Doctoral Student 3 11%
Student > Bachelor 3 11%
Researcher 3 11%
Professor 2 7%
Other 3 11%
Unknown 9 33%
Readers by discipline Count As %
Neuroscience 5 19%
Psychology 4 15%
Medicine and Dentistry 4 15%
Engineering 3 11%
Chemistry 1 4%
Other 1 4%
Unknown 9 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2017.
All research outputs
#17,898,929
of 22,981,247 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,428
of 3,197 outputs
Outputs of similar age
#226,781
of 317,132 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#56
of 67 outputs
Altmetric has tracked 22,981,247 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,197 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.