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Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study

Overview of attention for article published in Frontiers in Behavioral Neuroscience, June 2017
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Title
Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study
Published in
Frontiers in Behavioral Neuroscience, June 2017
DOI 10.3389/fnbeh.2017.00124
Pubmed ID
Authors

Zhi-bo Yu, Yan-bing Lv, Ling-heng Song, Dai-hong Liu, Xue-ling Huang, Xin-yue Hu, Zhi-wei Zuo, Yao Wang, Qian Yang, Jing Peng, Zhen-hua Zhou, Hai-tao Li

Abstract

Objective: The objective of this study was to investigate resting-state functional connectivity (FC) differences in insular sub-regions during the interictal phase in patients with migraine without aura (MWoA). Methods: Forty-nine MWoA patients (MWoA group) and 48 healthy individuals (healthy control group) were recruited for this study. All of the subjects underwent neurological examination and magnetic resonance imaging (MRI). The MRI data were processed using Brat 1.0 software to obtain a whole-brain FC diagram and using Rest 1.8 software to obtain the FC z-score of the sub-regions of both insulas (six sub-regions on each side). Therefore, there were a total of 12 regions of interest (ROIs) that were used as seed points for the statistical analysis. Results: There was abnormal FC between the insular sub-regions and multiple brain regions in the MWoA patients compared with the healthy control group, and a clear laterality was also observed. In addition, the FC z-score of certain sub-regions was negatively correlated with the disease duration. Conclusion: Different insular sub-regions are functionally associated with different regions of the brain and therefore have different functions. In MWoA, the FC between the insular sub-regions and other brain regions was mostly reduced, while a small amount was increased; additionally, the FC may be ipsilateral with a right-side advantage. Variations in the FC of insular sub-regions can be observed as an important indicator of MWoA.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 19%
Student > Ph. D. Student 5 16%
Researcher 5 16%
Student > Master 3 9%
Student > Postgraduate 3 9%
Other 0 0%
Unknown 10 31%
Readers by discipline Count As %
Neuroscience 8 25%
Medicine and Dentistry 7 22%
Psychology 2 6%
Arts and Humanities 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 1 3%
Unknown 12 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2017.
All research outputs
#17,899,796
of 22,981,247 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,428
of 3,197 outputs
Outputs of similar age
#226,361
of 315,488 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#51
of 61 outputs
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