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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Behavioral and Immunohistochemical Study of the Effects of Subchronic and Chronic Exposure to Glyphosate in Mice
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, August 2017
|
| DOI | 10.3389/fnbeh.2017.00146 |
| Pubmed ID | |
| Authors |
Yassine Ait Bali, Saadia Ba-Mhamed, Mohamed Bennis |
| Abstract |
Many epidemiological studies have described an adolescent-related psychiatric illness and sensorimotor deficits after Glyphosate based herbicide (GBH) exposure. GBH exposure in animal models of various ages suggests that it may be neurotoxic and could impact brain development and subsequently, behavior in adulthood. However, its neurotoxic effects on adolescent brain remain unclear and the results are limited. The present study was conducted to evaluate the neurobehavioral effects of GBH following acute, subchronic (6 weeks) and chronic (12 weeks) exposure (250 or 500 mg/kg/day) in mice treated from juvenile age until adulthood. Mice were subjected to behavioral testing with the open field (OF), the elevated plus maze, the tail suspension and Splash tests (STs). Their behaviors related to exploratory activity, anxiety and depression-like were recorded. After completion of the behavioral testing, adult mice were sacrificed and the expression of tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNc) and serotonin (5-HT) in the dorsal raphe nucleus (DRN), the basolateral amygdala (BLA) and the ventral medial prefrontal cortex (mPFC) was evaluated using immunohistochemical procedure. Our results indicate that unlike acute exposure, both subchronic and chronic exposure to GBH induced a decrease in body weight gain and locomotor activity, and an increase of anxiety and depression-like behavior levels. In addition, the immunohistochemical findings showed that only the chronic treatment induced a reduction of TH-immunoreactivity. However, both subchronic and chronic exposure produced a reduction of 5-HT-immunoreactivity in the DRN, BLA and ventral mPFC. Taken together, our data suggest that exposure to GBH from juvenile age through adulthood in mice leads to neurobehavioral changes that stem from the impairment of neuronal developmental processes. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 23% |
| Andorra | 1 | 4% |
| Germany | 1 | 4% |
| South Africa | 1 | 4% |
| Netherlands | 1 | 4% |
| Unknown | 16 | 62% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 92% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 112 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 17% |
| Student > Bachelor | 14 | 13% |
| Student > Ph. D. Student | 11 | 10% |
| Researcher | 8 | 7% |
| Student > Doctoral Student | 7 | 6% |
| Other | 10 | 9% |
| Unknown | 43 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 13% |
| Biochemistry, Genetics and Molecular Biology | 10 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 8% |
| Medicine and Dentistry | 6 | 5% |
| Agricultural and Biological Sciences | 4 | 4% |
| Other | 17 | 15% |
| Unknown | 52 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2022.
All research outputs
#2,113,223
of 24,350,163 outputs
Outputs from Frontiers in Behavioral Neuroscience
#351
of 3,355 outputs
Outputs of similar age
#40,696
of 321,424 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#8
of 59 outputs
Altmetric has tracked 24,350,163 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,355 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,424 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.