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Territorial Behavior and Social Stability in the Mouse Require Correct Expression of Imprinted Cdkn1c

Overview of attention for article published in Frontiers in Behavioral Neuroscience, February 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

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Title
Territorial Behavior and Social Stability in the Mouse Require Correct Expression of Imprinted Cdkn1c
Published in
Frontiers in Behavioral Neuroscience, February 2018
DOI 10.3389/fnbeh.2018.00028
Pubmed ID
Authors

Gráinne I. McNamara, Rosalind M. John, Anthony R. Isles

Abstract

Genomic imprinting, the epigenetic process by which transcription occurs from a single parental allele, is believed to influence social behaviors in mammals. An important social behavior is group living, which is enriched in Eutherian mammals relative to monotremes and marsupials. Group living facilitates resource acquisition, defense of territory and co-care of young, but requires a stable social group with complex inter-individual relationships. Co-occurring with increased group living in Eutherians is an increase in the number of imprinted loci, including that spanning the maternally expressedCdkn1c. Using a 'loss-of-imprinting' model ofCdkn1c(Cdkn1cBACx1), we demonstrated that twofold over expression ofCdkn1cresults in abnormal social behaviors. Although, our previous work indicated that maleCdkn1cBACx1mice were more dominant as measured by tube test encounters with unfamiliar wild-type (WT) males. Building upon this work, using more ecologically relevant assessments of social dominance, indicated that within their normal social group,Cdkn1cBACx1mice did not occupy higher ranking positions. Nevertheless, we find that presence ofCdkn1cBACx1animals within a group leads to instability of the normal social hierarchy, as indicated by greater variability in social rank within the group over time and an increase in territorial behavior in WT cage-mates. Consequently, these abnormal behaviors led to an increased incidence of fighting and wounding within the group. Taken together these data indicate that normal expression ofCdkn1cis required for maintaining stability of the social group and suggests that the acquisition of monoallelic expression ofCdkn1cmay have enhanced social behavior in Eutherian mammals to facilitate group living.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 25%
Student > Bachelor 6 19%
Student > Master 4 13%
Researcher 4 13%
Professor 2 6%
Other 3 9%
Unknown 5 16%
Readers by discipline Count As %
Neuroscience 7 22%
Biochemistry, Genetics and Molecular Biology 5 16%
Agricultural and Biological Sciences 5 16%
Psychology 3 9%
Medicine and Dentistry 3 9%
Other 2 6%
Unknown 7 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2018.
All research outputs
#4,543,837
of 23,020,670 outputs
Outputs from Frontiers in Behavioral Neuroscience
#742
of 3,201 outputs
Outputs of similar age
#88,902
of 330,210 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#21
of 70 outputs
Altmetric has tracked 23,020,670 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,201 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,210 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.