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Mendeley readers
Attention Score in Context
| Title |
Zebrafish Lacking Circadian Gene per2 Exhibit Visual Function Deficiency
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, March 2018
|
| DOI | 10.3389/fnbeh.2018.00053 |
| Pubmed ID | |
| Authors |
Deng-feng Huang, Ming-yong Wang, Wu Yin, Yu-qian Ma, Han Wang, Tian Xue, Da-long Ren, Bing Hu |
| Abstract |
The retina has an intrinsic circadian clock, but the importance of this clock for vision is unknown. Zebrafish offer many advantages for studying vertebrate vision and circadian rhythm. Here, we explored the role of zebrafishper2, a light-regulated gene, in visual behavior and the underlying mechanisms. We observed thatper2mutant zebrafish larvae showed decreased contrast sensitivity and visual acuity using optokinetic response (OKR) assays. Using a visual motor response (VMR) assay, we observed normal OFF responses but abnormal ON responses in mutant zebrafish larvae. Immunofluorescence showed that mutants had a normal morphology of cone photoreceptor cells and retinal organization. However, electron microscopy showed thatper2mutants displayed abnormal and decreased photoreceptor ribbon synapses with arciform density, which resulted in retinal ON pathway defect. We also examined the expression of three cone opsins by quantitative real-time PCR (qRT-PCR), and the expression of long-wave-sensitive opsin (opn1lw) and short-wave-sensitive opsin (opn1sw) was reduced in mutant zebrafish larvae. qRT-PCR analyses also showed a down-regulation of the clock genescry1baandbmal1bin the adult eye ofper2mutant zebrafish. This study identified a mechanism by which a clock gene affects visual function and defined important roles ofper2in retinal information processing. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 19% |
| Student > Master | 9 | 17% |
| Researcher | 6 | 11% |
| Student > Doctoral Student | 3 | 6% |
| Student > Bachelor | 3 | 6% |
| Other | 7 | 13% |
| Unknown | 16 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 28% |
| Neuroscience | 7 | 13% |
| Agricultural and Biological Sciences | 6 | 11% |
| Unspecified | 2 | 4% |
| Environmental Science | 2 | 4% |
| Other | 4 | 7% |
| Unknown | 18 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2018.
All research outputs
#15,493,741
of 23,025,074 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,240
of 3,201 outputs
Outputs of similar age
#213,307
of 333,587 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#61
of 71 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,201 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,587 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.