Title |
New Perspectives in Amblyopia Therapy on Adults: A Critical Role for the Excitatory/Inhibitory Balance
|
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Published in |
Frontiers in Cellular Neuroscience, January 2011
|
DOI | 10.3389/fncel.2011.00025 |
Pubmed ID | |
Authors |
Laura Baroncelli, Lamberto Maffei, Alessandro Sale |
Abstract |
Amblyopia is the most common form of impairment of visual function affecting one eye, with a prevalence of about 1-5% of the total world population. This pathology is caused by early abnormal visual experience with a functional imbalance between the two eyes owing to anisometropia, strabismus, or congenital cataract, resulting in a dramatic loss of visual acuity in an apparently healthy eye and various other perceptual abnormalities, including deficits in contrast sensitivity and in stereopsis. It is currently accepted that, due to a lack of sufficient plasticity within the brain, amblyopia is untreatable in adulthood. However, recent results obtained both in clinical trials and in animal models have challenged this traditional view, unmasking a previously unsuspected potential for promoting recovery after the end of the critical period for visual cortex plasticity. These studies point toward the intracortical inhibitory transmission as a crucial brake for therapeutic rehabilitation and recovery from amblyopia in the adult brain. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | <1% |
Singapore | 1 | <1% |
Mexico | 1 | <1% |
Belgium | 1 | <1% |
United States | 1 | <1% |
Poland | 1 | <1% |
Unknown | 111 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 18% |
Researcher | 19 | 16% |
Student > Bachelor | 18 | 15% |
Student > Master | 16 | 14% |
Other | 6 | 5% |
Other | 16 | 14% |
Unknown | 21 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 28 | 24% |
Medicine and Dentistry | 25 | 21% |
Agricultural and Biological Sciences | 16 | 14% |
Psychology | 12 | 10% |
Nursing and Health Professions | 6 | 5% |
Other | 4 | 3% |
Unknown | 26 | 22% |