Title |
Treating seizures and epilepsy with anticoagulants?
|
---|---|
Published in |
Frontiers in Cellular Neuroscience, January 2013
|
DOI | 10.3389/fncel.2013.00019 |
Pubmed ID | |
Authors |
Nicola Maggio, Ilan Blatt, Andreas Vlachos, David Tanne, Joab Chapman, Menahem Segal |
Abstract |
Thrombin is a serine protease playing an essential role in the blood coagulation cascade. Recent work, however, has identified a novel role for thrombin-mediated signaling pathways in the central nervous system. Binding of thrombin to protease-activated receptors (PARs) in the brain appears to have multiple actions affecting both health and disease. Specifically, thrombin has been shown to lead to the onset of seizures via PAR-1 activation. In this perspective article, we review the putative mechanisms by which thrombin causes seizures and epilepsy. We propose a potential role of PAR-1 antagonists and novel thrombin inhibitors as new, possible antiepileptic drugs. |
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