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Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

Overview of attention for article published in Frontiers in Cellular Neuroscience, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

blogs
1 blog
twitter
1 X user

Citations

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198 Dimensions

Readers on

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282 Mendeley
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Title
Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation
Published in
Frontiers in Cellular Neuroscience, January 2013
DOI 10.3389/fncel.2013.00022
Pubmed ID
Authors

Wai T. Wong

Abstract

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and age-related macular degeneration (AMD), share two characteristics in common: (1) a disease prevalence that increases markedly with advancing age, and (2) neuroinflammatory changes in which microglia, the primary resident immune cell of the CNS, feature prominently. These characteristics have led to the hypothesis that pathogenic mechanisms underlying age-related neurodegenerative disease involve aging changes in microglia. If correct, targeting features of microglial senescence may constitute a feasible therapeutic strategy. This review explores this hypothesis and its implications by considering the current knowledge on how microglia undergo change during aging and how the emergence of these aging phenotypes relate to significant alterations in microglial function. Evidence and theories on cellular mechanisms implicated in driving senescence in microglia are reviewed, as are "rejuvenative" measures and strategies that aim to reverse or ameliorate the aging microglial phenotype. Understanding and controlling microglial aging may represent an opportunity for elucidating disease mechanisms and for formulating novel therapies.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 282 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 3 1%
Australia 2 <1%
Sweden 1 <1%
United Kingdom 1 <1%
China 1 <1%
Spain 1 <1%
Unknown 273 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 72 26%
Researcher 45 16%
Student > Bachelor 33 12%
Student > Master 29 10%
Student > Doctoral Student 25 9%
Other 35 12%
Unknown 43 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 68 24%
Neuroscience 66 23%
Medicine and Dentistry 35 12%
Biochemistry, Genetics and Molecular Biology 24 9%
Immunology and Microbiology 7 2%
Other 25 9%
Unknown 57 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2013.
All research outputs
#2,740,233
of 22,701,287 outputs
Outputs from Frontiers in Cellular Neuroscience
#505
of 4,208 outputs
Outputs of similar age
#29,206
of 280,698 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#18
of 203 outputs
Altmetric has tracked 22,701,287 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,208 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,698 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 203 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.