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WNT signaling in neuronal maturation and synaptogenesis

Overview of attention for article published in Frontiers in Cellular Neuroscience, January 2013
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  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

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3 X users
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304 Mendeley
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Title
WNT signaling in neuronal maturation and synaptogenesis
Published in
Frontiers in Cellular Neuroscience, January 2013
DOI 10.3389/fncel.2013.00103
Pubmed ID
Authors

Silvana B. Rosso, Nibaldo C. Inestrosa

Abstract

The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system. Wnt components are key regulators of a variety of developmental processes, including embryonic patterning, cell specification, and cell polarity. In the nervous system, Wnt signaling also regulates the formation and function of neuronal circuits by controlling neuronal differentiation, axon outgrowth and guidance, dendrite development, synaptic function, and neuronal plasticity. Wnt factors can signal through three very well characterized cascades: canonical or β-catenin pathway, planar cell polarity pathway and calcium pathway that control different processes. However, divergent downstream cascades have been identified to control neuronal morphogenesis. In the nervous system, the expression of Wnt proteins is a highly controlled process. In addition, deregulation of Wnt signaling has been associated with neurodegenerative diseases. Here, we will review different aspects of neuronal and dendrite maturation, including spinogenesis and synaptogenesis. Finally, the role of Wnt pathway components on Alzheimer's disease will be revised.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 304 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Chile 2 <1%
Netherlands 1 <1%
Argentina 1 <1%
Unknown 297 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 71 23%
Researcher 50 16%
Student > Master 37 12%
Student > Bachelor 21 7%
Student > Doctoral Student 20 7%
Other 46 15%
Unknown 59 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 91 30%
Neuroscience 57 19%
Biochemistry, Genetics and Molecular Biology 47 15%
Medicine and Dentistry 14 5%
Pharmacology, Toxicology and Pharmaceutical Science 7 2%
Other 20 7%
Unknown 68 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#15,089,375
of 25,261,240 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,102
of 4,681 outputs
Outputs of similar age
#172,735
of 293,299 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#85
of 204 outputs
Altmetric has tracked 25,261,240 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,681 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,299 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 204 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.