Title |
Why looking at the whole hippocampus is not enough—a critical role for anteroposterior axis, subfield and activation analyses to enhance predictive value of hippocampal changes for Alzheimer’s disease diagnosis
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Published in |
Frontiers in Cellular Neuroscience, March 2014
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DOI | 10.3389/fncel.2014.00095 |
Pubmed ID | |
Authors |
Aleksandra Maruszak, Sandrine Thuret |
Abstract |
The hippocampus is one of the earliest affected brain regions in Alzheimer's disease (AD) and its dysfunction is believed to underlie the core feature of the disease-memory impairment. Given that hippocampal volume is one of the best AD biomarkers, our review focuses on distinct subfields within the hippocampus, pinpointing regions that might enhance the predictive value of current diagnostic methods. Our review presents how changes in hippocampal volume, shape, symmetry and activation are reflected by cognitive impairment and how they are linked with neurogenesis alterations. Moreover, we revisit the functional differentiation along the anteroposterior longitudinal axis of the hippocampus and discuss its relevance for AD diagnosis. Finally, we indicate that apart from hippocampal subfield volumetry, the characteristic pattern of hippocampal hyperactivation associated with seizures and neurogenesis changes is another promising candidate for an early AD biomarker that could become also a target for early interventions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 4 | 40% |
Switzerland | 1 | 10% |
France | 1 | 10% |
United States | 1 | 10% |
Canada | 1 | 10% |
Unknown | 2 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 80% |
Practitioners (doctors, other healthcare professionals) | 2 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Germany | 1 | <1% |
Unknown | 226 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 54 | 24% |
Researcher | 36 | 16% |
Student > Master | 20 | 9% |
Student > Bachelor | 16 | 7% |
Student > Postgraduate | 11 | 5% |
Other | 38 | 17% |
Unknown | 53 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 45 | 20% |
Psychology | 32 | 14% |
Medicine and Dentistry | 24 | 11% |
Agricultural and Biological Sciences | 20 | 9% |
Biochemistry, Genetics and Molecular Biology | 13 | 6% |
Other | 24 | 11% |
Unknown | 70 | 31% |