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Mendeley readers
Attention Score in Context
| Title |
Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, August 2014
|
| DOI | 10.3389/fncel.2014.00211 |
| Pubmed ID | |
| Authors |
Ricardo Cabezas, Marcos Ávila, Janneth Gonzalez, Ramon Santos El-Bachá, Eliana Báez, Luis Miguel García-Segura, Juan Camilo Jurado Coronel, Francisco Capani, Gloria Patricia Cardona-Gomez, George E. Barreto |
| Abstract |
The blood-brain barrier (BBB) is a tightly regulated interface in the Central Nervous System (CNS) that regulates the exchange of molecules in and out from the brain thus maintaining the CNS homeostasis. It is mainly composed of endothelial cells (ECs), pericytes and astrocytes that create a neurovascular unit (NVU) with the adjacent neurons. Astrocytes are essential for the formation and maintenance of the BBB by providing secreted factors that lead to the adequate association between the cells of the BBB and the formation of strong tight junctions. Under neurological disorders, such as chronic cerebral ischemia, brain trauma, Epilepsy, Alzheimer and Parkinson's Diseases, a disruption of the BBB takes place, involving a lost in the permeability of the barrier and phenotypical changes in both the ECs and astrocytes. In this aspect, it has been established that the process of reactive gliosis is a common feature of astrocytes during BBB disruption, which has a detrimental effect on the barrier function and a subsequent damage in neuronal survival. In this review we discuss the implications of astrocyte functions in the protection of the BBB, and in the development of Parkinson's disease (PD) and related disorders. Additionally, we highlight the current and future strategies in astrocyte protection aimed at the development of restorative therapies for the BBB in pathological conditions. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 593 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Colombia | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 587 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 120 | 20% |
| Student > Master | 89 | 15% |
| Student > Bachelor | 86 | 15% |
| Researcher | 55 | 9% |
| Student > Doctoral Student | 31 | 5% |
| Other | 69 | 12% |
| Unknown | 143 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 98 | 17% |
| Biochemistry, Genetics and Molecular Biology | 92 | 16% |
| Agricultural and Biological Sciences | 80 | 13% |
| Medicine and Dentistry | 47 | 8% |
| Engineering | 24 | 4% |
| Other | 94 | 16% |
| Unknown | 158 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2023.
All research outputs
#1,734,174
of 23,597,497 outputs
Outputs from Frontiers in Cellular Neuroscience
#208
of 4,387 outputs
Outputs of similar age
#18,225
of 231,126 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#2
of 60 outputs
Altmetric has tracked 23,597,497 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,387 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,126 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.