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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, August 2014
|
| DOI | 10.3389/fncel.2014.00218 |
| Pubmed ID | |
| Authors |
Julia Margulis, Steven Finkbeiner |
| Abstract |
Selective neuronal loss is a hallmark of neurodegenerative diseases, including Huntington's disease (HD). Although mutant huntingtin, the protein responsible for HD, is expressed ubiquitously, a subpopulation of neurons in the striatum is the first to succumb. In this review, we examine evidence that protein quality control pathways, including the ubiquitin proteasome system, autophagy, and chaperones, are significantly altered in striatal neurons. These alterations may increase the susceptibility of striatal neurons to mutant huntingtin-mediated toxicity. This novel view of HD pathogenesis has profound therapeutic implications: protein homeostasis pathways in the striatum may be valuable targets for treating HD and other misfolded protein disorders. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 2 | 3% |
| Portugal | 1 | 1% |
| Germany | 1 | 1% |
| United Kingdom | 1 | 1% |
| Belgium | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 63 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 26% |
| Researcher | 12 | 17% |
| Student > Bachelor | 10 | 14% |
| Student > Master | 9 | 13% |
| Student > Doctoral Student | 3 | 4% |
| Other | 8 | 11% |
| Unknown | 10 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 26% |
| Neuroscience | 18 | 26% |
| Biochemistry, Genetics and Molecular Biology | 9 | 13% |
| Medicine and Dentistry | 9 | 13% |
| Psychology | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 11 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2014.
All research outputs
#13,410,980
of 22,759,618 outputs
Outputs from Frontiers in Cellular Neuroscience
#1,870
of 4,225 outputs
Outputs of similar age
#109,582
of 230,235 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#24
of 62 outputs
Altmetric has tracked 22,759,618 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,225 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,235 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.