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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Protection after stroke: cellular effectors of neurovascular unit integrity
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, August 2014
|
| DOI | 10.3389/fncel.2014.00231 |
| Pubmed ID | |
| Authors |
Rafael Andres Posada-Duque, George E. Barreto, Gloria Patricia Cardona-Gomez |
| Abstract |
Neurological disorders are prevalent worldwide. Cerebrovascular diseases (CVDs), which account for 55% of all neurological diseases, are the leading cause of permanent disability, cognitive and motor disorders and dementia. Stroke affects the function and structure of blood-brain barrier, the loss of cerebral blood flow regulation, oxidative stress, inflammation and the loss of neural connections. Currently, no gold standard treatments are available outside the acute therapeutic window to improve outcome in stroke patients. Some promising candidate targets have been identified for the improvement of long-term recovery after stroke, such as Rho GTPases, cell adhesion proteins, kinases, and phosphatases. Previous studies by our lab indicated that Rho GTPases (Rac and RhoA) are involved in both tissue damage and survival, as these proteins are essential for the morphology and movement of neurons, astrocytes and endothelial cells, thus playing a critical role in the balance between cell survival and death. Treatment with a pharmacological inhibitor of RhoA/ROCK blocks the activation of the neurodegeneration cascade. In addition, Rac and synaptic adhesion proteins (p120 catenin and N-catenin) play critical roles in protection against cerebral infarction and in recovery by supporting the neurovascular unit and cytoskeletal remodeling activity to maintain the integrity of the brain parenchyma. Interestingly, neuroprotective agents, such as atorvastatin, and CDK5 silencing after cerebral ischemia and in a glutamate-induced excitotoxicity model may act on the same cellular effectors to recover neurovascular unit integrity. Therefore, future efforts must focus on individually targeting the structural and functional roles of each effector of neurovascular unit and the interactions in neural and non-neural cells in the post-ischemic brain and address how to promote the recovery or prevent the loss of homeostasis in the short, medium and long term. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| Colombia | 1 | <1% |
| Romania | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 141 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 20% |
| Researcher | 19 | 13% |
| Student > Ph. D. Student | 17 | 12% |
| Student > Master | 15 | 10% |
| Student > Doctoral Student | 13 | 9% |
| Other | 25 | 17% |
| Unknown | 27 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 29 | 20% |
| Agricultural and Biological Sciences | 27 | 19% |
| Medicine and Dentistry | 24 | 17% |
| Biochemistry, Genetics and Molecular Biology | 13 | 9% |
| Engineering | 4 | 3% |
| Other | 21 | 14% |
| Unknown | 27 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2019.
All research outputs
#17,725,418
of 22,761,738 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,922
of 4,226 outputs
Outputs of similar age
#155,803
of 231,202 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#39
of 63 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,226 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,202 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.