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Diffusion dynamics of synaptic molecules during inhibitory postsynaptic plasticity

Overview of attention for article published in Frontiers in Cellular Neuroscience, September 2014
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Title
Diffusion dynamics of synaptic molecules during inhibitory postsynaptic plasticity
Published in
Frontiers in Cellular Neuroscience, September 2014
DOI 10.3389/fncel.2014.00300
Pubmed ID
Authors

Enrica Maria Petrini, Andrea Barberis

Abstract

The plasticity of inhibitory transmission is expected to play a key role in the modulation of neuronal excitability and network function. Over the last two decades, the investigation of the determinants of inhibitory synaptic plasticity has allowed distinguishing presynaptic and postsynaptic mechanisms. While there has been a remarkable progress in the characterization of presynaptically-expressed plasticity of inhibition, the postsynaptic mechanisms of inhibitory long-term synaptic plasticity only begin to be unraveled. At postsynaptic level, the expression of inhibitory synaptic plasticity involves the rearrangement of the postsynaptic molecular components of the GABAergic synapse, including GABAA receptors, scaffold proteins and structural molecules. This implies a dynamic modulation of receptor intracellular trafficking and receptor surface lateral diffusion, along with regulation of the availability and distribution of scaffold proteins. This Review will focus on the mechanisms of the multifaceted molecular reorganization of the inhibitory synapse during postsynaptic plasticity, with special emphasis on the key role of protein dynamics to ensure prompt and reliable activity-dependent adjustments of synaptic strength.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
France 1 <1%
Sweden 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 116 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 28%
Researcher 21 17%
Student > Master 16 13%
Student > Bachelor 10 8%
Professor 8 7%
Other 18 15%
Unknown 14 12%
Readers by discipline Count As %
Neuroscience 41 34%
Agricultural and Biological Sciences 37 31%
Biochemistry, Genetics and Molecular Biology 6 5%
Physics and Astronomy 6 5%
Medicine and Dentistry 4 3%
Other 7 6%
Unknown 20 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2014.
All research outputs
#17,732,540
of 22,771,140 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,923
of 4,230 outputs
Outputs of similar age
#169,444
of 251,970 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#47
of 88 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,230 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,970 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.