↓ Skip to main content

Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism

Overview of attention for article published in Frontiers in Cellular Neuroscience, November 2014
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

blogs
2 blogs
twitter
13 X users

Citations

dimensions_citation
43 Dimensions

Readers on

mendeley
92 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism
Published in
Frontiers in Cellular Neuroscience, November 2014
DOI 10.3389/fncel.2014.00397
Pubmed ID
Authors

Emily L. Casanova, Manuel F. Casanova

Abstract

Postmortem neuropathological studies of autism consistently reveal distinctive types of malformations, including cortical dysplasias, heterotopias, and various neuronomorphometric abnormalities. In keeping with these observations, we review here that 88% of high-risk genes for autism influence neural induction and early maturation of the neuroblast. In addition, 80% of these same genes influence later stages of differentiation, including neurite and synapse development, suggesting that these gene products exhibit long-lasting developmental effects on cell development as well as elements of redundancy in processes of neural proliferation, growth, and maturation. We also address the putative genetic overlap of autism with conditions like epilepsy and schizophrenia, with implications to shared and divergent etiologies. This review imports the necessity of a frameshift in our understanding of the neurodevelopmental basis of autism to include all stages of neuronal maturation, ranging from neural induction to synaptogenesis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Brazil 1 1%
Unknown 90 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 18%
Student > Ph. D. Student 14 15%
Student > Master 11 12%
Student > Bachelor 10 11%
Other 6 7%
Other 15 16%
Unknown 19 21%
Readers by discipline Count As %
Neuroscience 19 21%
Agricultural and Biological Sciences 15 16%
Biochemistry, Genetics and Molecular Biology 10 11%
Medicine and Dentistry 10 11%
Psychology 5 5%
Other 12 13%
Unknown 21 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2016.
All research outputs
#1,787,542
of 22,771,140 outputs
Outputs from Frontiers in Cellular Neuroscience
#224
of 4,230 outputs
Outputs of similar age
#26,470
of 362,502 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#5
of 82 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,230 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,502 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.