Title |
Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
|
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Published in |
Frontiers in Cellular Neuroscience, December 2014
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DOI | 10.3389/fncel.2014.00430 |
Pubmed ID | |
Authors |
Francesca Calabrese, Andrea C. Rossetti, Giorgio Racagni, Peter Gass, Marco A. Riva, Raffaella Molteni |
Abstract |
Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system. For this, their expression in both systems is under a tight regulatory control. However, pathological conditions may lead to an overproduction of pro-inflammatory cytokines that may have a detrimental impact on central nervous system. In particular, they may damage neuronal structure and function leading to deficits of neuroplasticity, the ability of nervous system to perceive, respond and adapt to external or internal stimuli. In search of the mechanisms by which pro-inflammatory cytokines may affect this crucial brain capability, we will discuss one of the most interesting hypotheses: the involvement of the neurotrophin brain-derived neurotrophic factor (BDNF), which represents one of the major mediators of neuroplasticity. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | <1% |
Ireland | 1 | <1% |
Italy | 1 | <1% |
Taiwan | 1 | <1% |
Canada | 1 | <1% |
Russia | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 482 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 93 | 19% |
Researcher | 72 | 15% |
Student > Bachelor | 70 | 14% |
Student > Master | 58 | 12% |
Student > Doctoral Student | 34 | 7% |
Other | 79 | 16% |
Unknown | 85 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 105 | 21% |
Medicine and Dentistry | 86 | 18% |
Agricultural and Biological Sciences | 56 | 11% |
Psychology | 33 | 7% |
Biochemistry, Genetics and Molecular Biology | 30 | 6% |
Other | 69 | 14% |
Unknown | 112 | 23% |