Title |
Bone morphogenetic protein signaling in vertebrate motor neurons and neuromuscular communication
|
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Published in |
Frontiers in Cellular Neuroscience, January 2015
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DOI | 10.3389/fncel.2014.00453 |
Pubmed ID | |
Authors |
Nelson Osses, Juan P. Henríquez |
Abstract |
An accurate communication between motor neurons and skeletal muscle fibers is required for the proper assembly, growth and maintenance of neuromuscular junctions (NMJs). Several signaling and extracellular matrix molecules play stimulatory and inhibitory roles on the assembly of functional synapses. Studies in Drosophila have revealed crucial functions for early morphogens, such as members of the Wnt and Bone Morphogenetic Proteins (BMP) signaling pathways, during the assembly and maturation of the NMJ. Here, we bring together recent findings that led us to propose that BMPs also work in vertebrate organisms as diffusible cues to communicate motor neurons and skeletal muscles. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 29% |
Researcher | 11 | 22% |
Student > Bachelor | 6 | 12% |
Student > Master | 4 | 8% |
Student > Doctoral Student | 2 | 4% |
Other | 5 | 10% |
Unknown | 7 | 14% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Medicine and Dentistry | 3 | 6% |
Other | 5 | 10% |
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