Title |
Gene expression changes in spinal motoneurons of the SOD1G93A transgenic model for ALS after treatment with G-CSF
|
---|---|
Published in |
Frontiers in Cellular Neuroscience, January 2015
|
DOI | 10.3389/fncel.2014.00464 |
Pubmed ID | |
Authors |
Alexandre Henriques, Stefan Kastner, Eva Chatzikonstantinou, Claudia Pitzer, Christian Plaas, Friederike Kirsch, Oliver Wafzig, Carola Krüger, Robert Spoelgen, Jose-Luis Gonzalez De Aguilar, Norbert Gretz, Armin Schneider |
Abstract |
Amyotrophic lateral sclerosis (ALS) is an incurable fatal motoneuron disease with a lifetime risk of approximately 1:400. It is characterized by progressive weakness, muscle wasting, and death ensuing 3-5 years after diagnosis. Granulocyte-colony stimulating factor (G-CSF) is a drug candidate for ALS, with evidence for efficacy from animal studies and interesting data from pilot clinical trials. To gain insight into the disease mechanisms and mode of action of G-CSF, we performed gene expression profiling on isolated lumbar motoneurons from SOD1(G93A) mice, the most frequently studied animal model for ALS, with and without G-CSF treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 20% |
Researcher | 8 | 18% |
Student > Bachelor | 5 | 11% |
Student > Master | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Other | 8 | 18% |
Unknown | 8 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 22% |
Agricultural and Biological Sciences | 10 | 22% |
Neuroscience | 7 | 16% |
Medicine and Dentistry | 5 | 11% |
Nursing and Health Professions | 1 | 2% |
Other | 2 | 4% |
Unknown | 10 | 22% |