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Gene expression changes in spinal motoneurons of the SOD1G93A transgenic model for ALS after treatment with G-CSF

Overview of attention for article published in Frontiers in Cellular Neuroscience, January 2015
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  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

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Title
Gene expression changes in spinal motoneurons of the SOD1G93A transgenic model for ALS after treatment with G-CSF
Published in
Frontiers in Cellular Neuroscience, January 2015
DOI 10.3389/fncel.2014.00464
Pubmed ID
Authors

Alexandre Henriques, Stefan Kastner, Eva Chatzikonstantinou, Claudia Pitzer, Christian Plaas, Friederike Kirsch, Oliver Wafzig, Carola Krüger, Robert Spoelgen, Jose-Luis Gonzalez De Aguilar, Norbert Gretz, Armin Schneider

Abstract

Amyotrophic lateral sclerosis (ALS) is an incurable fatal motoneuron disease with a lifetime risk of approximately 1:400. It is characterized by progressive weakness, muscle wasting, and death ensuing 3-5 years after diagnosis. Granulocyte-colony stimulating factor (G-CSF) is a drug candidate for ALS, with evidence for efficacy from animal studies and interesting data from pilot clinical trials. To gain insight into the disease mechanisms and mode of action of G-CSF, we performed gene expression profiling on isolated lumbar motoneurons from SOD1(G93A) mice, the most frequently studied animal model for ALS, with and without G-CSF treatment.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Researcher 8 18%
Student > Bachelor 5 11%
Student > Master 4 9%
Student > Doctoral Student 3 7%
Other 8 18%
Unknown 8 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 22%
Agricultural and Biological Sciences 10 22%
Neuroscience 7 16%
Medicine and Dentistry 5 11%
Nursing and Health Professions 1 2%
Other 2 4%
Unknown 10 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2015.
All research outputs
#14,672,193
of 22,786,691 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,360
of 4,234 outputs
Outputs of similar age
#195,938
of 352,057 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#39
of 82 outputs
Altmetric has tracked 22,786,691 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,234 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,057 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.