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Mendeley readers
Attention Score in Context
| Title |
Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, March 2015
|
| DOI | 10.3389/fncel.2015.00082 |
| Pubmed ID | |
| Authors |
Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Bogusława Budziszewska, Marta Kubera, Władysław Lasoń, Katarzyna Popiołek-Barczyk, Joanna Mika, Krzysztof Wędzony, Agnieszka Basta-Kaim |
| Abstract |
Several lines of evidence suggest that the dysregulation of the immune system is an important factor in the development of depression. Microglia are the resident macrophages of the central nervous system and a key player in innate immunity of the brain. We hypothesized that prenatal stress (an animal model of depression) as a priming factor could affect microglial cells and might lead to depressive-like disturbances in adult male rat offspring. We investigated the behavioral changes (sucrose preference test, Porsolt test), the expression of C1q and CD40 mRNA and the level of microglia (Iba1 positive) in 3-month-old control and prenatally stressed male offspring rats. In addition, we characterized the morphological and biochemical parameters of potentially harmful (NO, iNOS, IL-1β, IL-18, IL-6, TNF-α, CCL2, CXCL12, CCR2, CXCR4) and beneficial (insulin-like growth factor-1 (IGF-1), brain derived neurotrophic factor (BDNF)) phenotypes in cultures of microglia obtained from the cortices of 1-2 days old control and prenatally stressed pups. The adult prenatally stressed rats showed behavioral (anhedonic- and depression-like) disturbances, enhanced expression of microglial activation markers and an increased number of Iba1-immunopositive cells in the hippocampus and frontal cortex. The morphology of glia was altered in cultures from prenatally stressed rats, as demonstrated by immunofluorescence microscopy. Moreover, in these cultures, we observed enhanced expression of CD40 and MHC II and release of pro-inflammatory cytokines, including IL-1β, IL-18, TNF-α and IL-6. Prenatal stress significantly up-regulated levels of the chemokines CCL2, CXCL12 and altered expression of their receptors, CCR2 and CXCR4 while IGF-1 production was suppressed in cultures of microglia from prenatally stressed rats. Our results suggest that prenatal stress may lead to excessive microglia activation and contribute to the behavioral changes observed in depression in adulthood. |
Mendeley readers
The data shown below were compiled from readership statistics for 174 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| Netherlands | 1 | <1% |
| Unknown | 170 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 21% |
| Researcher | 23 | 13% |
| Student > Doctoral Student | 22 | 13% |
| Student > Bachelor | 22 | 13% |
| Student > Master | 17 | 10% |
| Other | 25 | 14% |
| Unknown | 29 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 51 | 29% |
| Agricultural and Biological Sciences | 28 | 16% |
| Medicine and Dentistry | 19 | 11% |
| Biochemistry, Genetics and Molecular Biology | 8 | 5% |
| Psychology | 7 | 4% |
| Other | 21 | 12% |
| Unknown | 40 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2016.
All research outputs
#18,407,102
of 22,800,560 outputs
Outputs from Frontiers in Cellular Neuroscience
#3,248
of 4,239 outputs
Outputs of similar age
#188,687
of 259,037 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#87
of 105 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,239 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.