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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson’s disease
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, April 2015
|
| DOI | 10.3389/fncel.2015.00097 |
| Pubmed ID | |
| Authors |
Mariana Acquarone, Thiago M. de Melo, Fernanda Meireles, Jordano Brito-Moreira, Gabriel Oliveira, Sergio T. Ferreira, Newton G. Castro, Fernanda Tovar-Moll, Jean-Christophe Houzel, Stevens K. Rehen |
| Abstract |
Parkinson's disease (PD) is an incurable progressive neurodegenerative disorder. Clinical presentation of PD stems largely from the loss of dopaminergic neurons in the nigrostriatal dopaminergic pathway, motivating experimental strategies of replacement based on cell therapy. Transplantation of dopaminergic neurons derived from embryonic stem cells significantly improves motor functions in rodent and non-human primate models of PD. However, protocols to generate dopaminergic neurons from embryonic stem cells generally meet with low efficacy and high risk of teratoma formation upon transplantation. To address these issues, we have pre-treated undifferentiated mouse embryonic stem cells (mESCs) with the DNA alkylating agent mitomycin C (MMC) before transplantation. MMC treatment of cultures prevented tumorigenesis in a 12 week follow-up after mESCs were injected in nude mice. In 6-OH-dopamine-lesioned mice, intrastriatal injection of MMC-treated mESCs markedly improved motor function without tumor formation for as long as 15 months. Furthermore, we show that halting mitotic activity of undifferentiated mESCs induces a four-fold increase in dopamine release following in vitro differentiation. Our findings indicate that treating mESCs with MMC prior to intrastriatal transplant is an effective to strategy that could be further investigated as a novel alternative for treatment of PD. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 26% |
| Switzerland | 1 | 5% |
| Norway | 1 | 5% |
| Russia | 1 | 5% |
| Canada | 1 | 5% |
| Mexico | 1 | 5% |
| Brazil | 1 | 5% |
| India | 1 | 5% |
| Unknown | 7 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 74% |
| Scientists | 3 | 16% |
| Science communicators (journalists, bloggers, editors) | 2 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 3% |
| Unknown | 57 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 19% |
| Student > Master | 11 | 19% |
| Student > Bachelor | 10 | 17% |
| Student > Ph. D. Student | 9 | 15% |
| Student > Doctoral Student | 5 | 8% |
| Other | 9 | 15% |
| Unknown | 4 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 29% |
| Neuroscience | 13 | 22% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Medicine and Dentistry | 6 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 7 | 12% |
| Unknown | 5 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 80. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2018.
All research outputs
#532,340
of 25,393,455 outputs
Outputs from Frontiers in Cellular Neuroscience
#52
of 4,693 outputs
Outputs of similar age
#6,239
of 279,526 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#1
of 101 outputs
Altmetric has tracked 25,393,455 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,693 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,526 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.