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Attention Score in Context
| Title |
Aged neuronal nitric oxide knockout mice show preserved olfactory learning in both social recognition and odor-conditioning tasks
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, March 2015
|
| DOI | 10.3389/fncel.2015.00105 |
| Pubmed ID | |
| Authors |
Bronwen M. James, Qin Li, Lizhu Luo, Keith M. Kendrick |
| Abstract |
There is evidence for both neurotoxic and neuroprotective roles of nitric oxide (NO) in the brain and changes in the expression of the neuronal isoform of NO synthase (nNOS) gene occur during aging. The current studies have investigated potential support for either a neurotoxic or neuroprotective role of NO derived from nNOS in the context of aging by comparing olfactory learning and locomotor function in young compared to old nNOS knockout (nNOS(-/-)) and wildtype control mice. Tasks involving social recognition and olfactory conditioning paradigms showed that old nNOS(-/-) animals had improved retention of learning compared to similar aged wildtype controls. Young nNOS(-/-) animals showed superior reversal learning to wildtypes in a conditioned learning task, although their performance was weakened with age. Interestingly, whereas young nNOS(-/-) animals were impaired in long term memory for social odors compared to wildtype controls, in old animals this pattern was reversed, possibly indicating beneficial compensatory changes influencing olfactory memory may occur during aging in nNOS(-/-) animals. Possibly such compensatory changes may have involved increased NO from other NOS isoforms since the memory deficit in young nNOS(-/-) animals could be rescued by the NO-donor, molsidomine. Both nNOS(-/-) and wildtype animals showed an age-associated decline in locomotor activity although young nNOS(-/-) animals were significantly more active than wildtypes, possibly due to an increased interest in novelty. Overall our findings suggest that lack of NO release via nNOS may protect animals to some extent against age-associated cognitive decline in memory tasks typically involving olfactory and hippocampal regions, but not against declines in reversal learning or locomotor activity. |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 27 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 21% |
| Student > Master | 4 | 14% |
| Researcher | 4 | 14% |
| Student > Bachelor | 3 | 10% |
| Professor | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 7 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 28% |
| Neuroscience | 5 | 17% |
| Sports and Recreations | 2 | 7% |
| Psychology | 2 | 7% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 9 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2015.
All research outputs
#15,489,831
of 23,018,998 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,687
of 4,265 outputs
Outputs of similar age
#157,827
of 263,954 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#63
of 96 outputs
Altmetric has tracked 23,018,998 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,265 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,954 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.