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Mendeley readers
Attention Score in Context
| Title |
Differential expression of sirtuins in the aging rat brain
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, May 2015
|
| DOI | 10.3389/fncel.2015.00167 |
| Pubmed ID | |
| Authors |
Nady Braidy, Anne Poljak, Ross Grant, Tharusha Jayasena, Hussein Mansour, Tailoi Chan-Ling, George Smythe, Perminder Sachdev, Gilles J. Guillemin |
| Abstract |
Although there are seven mammalian sirtuins (SIRT1-7), little is known about their expression in the aging brain. To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of "physiologically" aged Wistar rats. We tested mRNA and protein expression levels of rat SIRT1-7, and the levels of associated proteins in the brain using RT-PCR and western blotting. Our data shows that SIRT1 expression increases with age, concurrently with increased acetylated p53 levels in all brain regions investigated. SIRT2 and FOXO3a protein levels increased only in the occipital lobe. SIRT3-5 expression declined significantly in the hippocampus and frontal lobe, associated with increases in superoxide and fatty acid oxidation levels, and acetylated CPS-1 protein expression, and a reduction in MnSOD level. While SIRT6 expression declines significantly with age acetylated H3K9 protein expression is increased throughout the brain. SIRT7 and Pol I protein expression increased in the frontal lobe. This study identifies previously unknown roles for sirtuins in regulating cellular homeostasis and healthy aging. |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | <1% |
| Malaysia | 1 | <1% |
| United States | 1 | <1% |
| India | 1 | <1% |
| Unknown | 133 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 20% |
| Student > Master | 20 | 15% |
| Researcher | 19 | 14% |
| Student > Bachelor | 17 | 12% |
| Professor | 8 | 6% |
| Other | 25 | 18% |
| Unknown | 20 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 20% |
| Agricultural and Biological Sciences | 26 | 19% |
| Neuroscience | 21 | 15% |
| Medicine and Dentistry | 13 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 12 | 9% |
| Unknown | 31 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2015.
All research outputs
#1,935,413
of 22,807,037 outputs
Outputs from Frontiers in Cellular Neuroscience
#267
of 4,241 outputs
Outputs of similar age
#26,486
of 264,519 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#10
of 113 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,241 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,519 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.