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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Astroglial calcium signaling displays short-term plasticity and adjusts synaptic efficacy
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, May 2015
|
| DOI | 10.3389/fncel.2015.00189 |
| Pubmed ID | |
| Authors |
Jérémie Sibille, Jonathan Zapata, Jérémie Teillon, Nathalie Rouach |
| Abstract |
Astrocytes are dynamic signaling brain elements able to sense neuronal inputs and to respond by complex calcium signals, which are thought to represent their excitability. Such signaling has been proposed to modulate, or not, neuronal activities ranging from basal synaptic transmission to epileptiform discharges. However, whether calcium signaling in astrocytes exhibits activity-dependent changes and acutely modulates short-term synaptic plasticity is currently unclear. We here show, using dual recordings of astroglial calcium signals and synaptic transmission, that calcium signaling in astrocytes displays, concomitantly to excitatory synapses, short-term plasticity in response to prolonged repetitive and tetanic stimulations of Schaffer collaterals. We also found that acute inhibition of calcium signaling in astrocytes by intracellular calcium chelation rapidly potentiates excitatory synaptic transmission and short-term plasticity of Shaffer collateral CA1 synapses, i.e., paired-pulse facilitation and responses to tetanic and prolonged repetitive stimulation. These data reveal that calcium signaling of astrocytes is plastic and down-regulates basal transmission and short-term plasticity of hippocampal CA1 glutamatergic synapses. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 2% |
| Germany | 2 | 2% |
| United States | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 111 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 29% |
| Researcher | 22 | 19% |
| Student > Master | 14 | 12% |
| Student > Bachelor | 8 | 7% |
| Student > Doctoral Student | 5 | 4% |
| Other | 17 | 15% |
| Unknown | 17 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 44 | 38% |
| Agricultural and Biological Sciences | 26 | 22% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Medicine and Dentistry | 6 | 5% |
| Psychology | 3 | 3% |
| Other | 12 | 10% |
| Unknown | 20 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#13,202,980
of 22,807,037 outputs
Outputs from Frontiers in Cellular Neuroscience
#1,742
of 4,241 outputs
Outputs of similar age
#123,109
of 266,724 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#55
of 116 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,241 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,724 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.