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Mendeley readers
Attention Score in Context
| Title |
Myosin X regulates neuronal radial migration through interacting with N-cadherin
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, August 2015
|
| DOI | 10.3389/fncel.2015.00326 |
| Pubmed ID | |
| Authors |
Mingming Lai, Ye Guo, Jun Ma, Huali Yu, Dongdong Zhao, Wenqiang Fan, Xingda Ju, Muhammad A. Sheikh, Yousra S. Malik, Wencheng Xiong, Weixiang Guo, Xiaojuan Zhu |
| Abstract |
Proper brain function depends on correct neuronal migration during development, which is known to be regulated by cytoskeletal dynamics and cell-cell adhesion. Myosin X (Myo10), an uncharacteristic member of the myosin family, is an important regulator of cytoskeleton that modulates cell motilities in many different cellular contexts. We previously reported that Myo10 was required for neuronal migration in the developing cerebral cortex, but the underlying mechanism was still largely unknown. Here, we found that knockdown of Myo10 expression disturbed the adherence of migrating neurons to radial glial fibers through abolishing surface Neuronal cadherin (N-cadherin) expression, thereby impaired neuronal migration in the developmental cortex. Next, we found Myo10 interacted with N-cadherin cellular domain through its FERM domain. Furthermore, we found knockdown of Myo10 disrupted N-cadherin subcellular distribution and led to localization of N-cadherin into Golgi apparatus and endosomal sorting vesicle. Taking together, these results reveal a novel mechanism of Myo10 interacting with N-cadherin and regulating its cell-surface expression, which is required for neuronal adhesion and migration. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 21% |
| Student > Doctoral Student | 4 | 17% |
| Researcher | 4 | 17% |
| Professor > Associate Professor | 2 | 8% |
| Lecturer | 1 | 4% |
| Other | 4 | 17% |
| Unknown | 4 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 33% |
| Biochemistry, Genetics and Molecular Biology | 7 | 29% |
| Neuroscience | 3 | 13% |
| Physics and Astronomy | 1 | 4% |
| Engineering | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 4 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2015.
All research outputs
#14,235,639
of 22,824,164 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,199
of 4,245 outputs
Outputs of similar age
#137,701
of 266,186 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#58
of 135 outputs
Altmetric has tracked 22,824,164 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,245 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,186 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.