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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, September 2015
|
| DOI | 10.3389/fncel.2015.00354 |
| Pubmed ID | |
| Authors |
Sophia Bardehle, Victoria A. Rafalski, Katerina Akassoglou |
| Abstract |
Blood proteins at the neurovascular unit (NVU) are emerging as important molecular determinants of communication between the brain and the immune system. Over the past two decades, roles for the plasminogen activation (PA)/plasmin system in fibrinolysis have been extended from peripheral dissolution of blood clots to the regulation of central nervous system (CNS) functions in physiology and disease. In this review, we discuss how fibrin and its proteolytic degradation affect neuroinflammatory, degenerative and repair processes. In particular, we focus on novel functions of fibrin-the final product of the coagulation cascade and the main substrate of plasmin-in the activation of immune responses and trafficking of immune cells into the brain. We also comment on the suitability of the coagulation and fibrinolytic systems as potential biomarkers and drug targets in diseases, such as multiple sclerosis (MS), Alzheimer's disease (AD) and stroke. Studying coagulation and fibrinolysis as major molecular pathways that regulate cellular functions at the NVU has the potential to lead to the development of novel strategies for the detection and treatment of neurologic diseases. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 25% |
| United States | 1 | 13% |
| Switzerland | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 20% |
| Researcher | 16 | 18% |
| Student > Master | 13 | 14% |
| Professor | 7 | 8% |
| Student > Bachelor | 7 | 8% |
| Other | 21 | 23% |
| Unknown | 8 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 20% |
| Neuroscience | 16 | 18% |
| Agricultural and Biological Sciences | 10 | 11% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Immunology and Microbiology | 6 | 7% |
| Other | 15 | 17% |
| Unknown | 16 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2016.
All research outputs
#6,108,207
of 22,828,180 outputs
Outputs from Frontiers in Cellular Neuroscience
#1,106
of 4,247 outputs
Outputs of similar age
#66,070
of 245,084 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#30
of 140 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 4,247 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,084 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.