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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain
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|---|---|
| Published in |
Frontiers in Cellular Neuroscience, September 2015
|
| DOI | 10.3389/fncel.2015.00379 |
| Pubmed ID | |
| Authors |
Patricia Rivera, Eduardo Blanco, Laura Bindila, Francisco Alen, Antonio Vargas, Leticia Rubio, Francisco J. Pavón, Antonia Serrano, Beat Lutz, Fernando Rodríguez de Fonseca, Juan Suárez |
| Abstract |
Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective effects of the selective CB1 receptor agonist ACEA, the selective CB2 receptor agonist JWH133 and the fatty-acid amide-hydrolase (FAAH) inhibitor URB597, which enhances endocannabinoid receptor activity, on NPC proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. We performed immunohistochemical and stereological analyses of cells expressing the mitotic phosphorylation of histone-3 (phospho-H3+) and the replicating cell DNA marker 5-bromo-2'-deoxyuridine (BrdU+) in the main neurogenic zones of adult brain: subgranular zone of dentate gyrus (SGZ), subventricular zone of lateral ventricles (SVZ) and hypothalamus. Animals were allowed ad libitum ethanol intake (7.3 ± 1.1 g/kg/day) after a controlled isocaloric pair-feeding period of sucrose and alcoholic diets. Alcohol intake reduced the number of BrdU+ cells in SGZ, SVZ, and hypothalamus. The treatments (URB597, ACEA, JWH133) exerted a differential increase in alcohol consumption over time, but JWH133 specifically counteracted the deleterious effect of ethanol on NPC proliferation in the SVZ and SGZ, and ACEA reversed this effect in the SGZ only. JWH133 also induced an increased number of BrdU+ cells expressing neuron-specific β3-tubulin in the SVZ and SGZ. These results indicated that the specific activation of CB2 receptors rescued alcohol-induced impaired NPC proliferation, which is a potential clinical interest for the risk of neural damage in alcohol dependence. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 12% |
| United States | 2 | 12% |
| Japan | 1 | 6% |
| United Kingdom | 1 | 6% |
| Australia | 1 | 6% |
| Netherlands | 1 | 6% |
| Switzerland | 1 | 6% |
| Unknown | 8 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 88% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Unknown | 57 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 16% |
| Professor | 8 | 14% |
| Student > Bachelor | 8 | 14% |
| Researcher | 8 | 14% |
| Student > Master | 8 | 14% |
| Other | 10 | 17% |
| Unknown | 7 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 13 | 22% |
| Medicine and Dentistry | 10 | 17% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Agricultural and Biological Sciences | 7 | 12% |
| Psychology | 3 | 5% |
| Other | 5 | 9% |
| Unknown | 12 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2019.
All research outputs
#2,251,909
of 24,229,740 outputs
Outputs from Frontiers in Cellular Neuroscience
#324
of 4,503 outputs
Outputs of similar age
#31,218
of 278,984 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#10
of 131 outputs
Altmetric has tracked 24,229,740 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,503 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,984 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.