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Mendeley readers
Attention Score in Context
| Title |
Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, October 2015
|
| DOI | 10.3389/fncel.2015.00396 |
| Pubmed ID | |
| Authors |
Tet Woo Lee, Vicky W. K. Tsang, Nigel P. Birch |
| Abstract |
Although its roles in the vascular space are most well-known, tissue plasminogen activator (tPA) is widely expressed in the developing and adult nervous system, where its activity is believed to be regulated by neuroserpin, a predominantly brain-specific member of the serpin family of protease inhibitors. In the normal physiological state, tPA has been shown to play roles in the development and plasticity of the nervous system. Ischemic damage, however, may lead to excess tPA activity in the brain and this is believed to contribute to neurodegeneration. In this article, we briefly review the physiological and pathological roles of tPA in the nervous system, which includes neuronal migration, axonal growth, synaptic plasticity, neuroprotection and neurodegeneration, as well as a contribution to neurological disease. We summarize tPA's multiple mechanisms of action and also highlight the contributions of the inhibitor neuroserpin to these processes. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 20% |
| Researcher | 9 | 17% |
| Student > Master | 8 | 15% |
| Student > Bachelor | 5 | 9% |
| Student > Doctoral Student | 3 | 6% |
| Other | 10 | 19% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 19% |
| Agricultural and Biological Sciences | 9 | 17% |
| Biochemistry, Genetics and Molecular Biology | 8 | 15% |
| Medicine and Dentistry | 7 | 13% |
| Immunology and Microbiology | 2 | 4% |
| Other | 9 | 17% |
| Unknown | 9 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2015.
All research outputs
#2,654,918
of 22,830,751 outputs
Outputs from Frontiers in Cellular Neuroscience
#455
of 4,247 outputs
Outputs of similar age
#38,590
of 279,229 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#16
of 119 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,247 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,229 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.