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Attention Score in Context
| Title |
The Shaping of Two Distinct Dendritic Spikes by A-Type Voltage-Gated K+ Channels
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, December 2015
|
| DOI | 10.3389/fncel.2015.00469 |
| Pubmed ID | |
| Authors |
Sungchil Yang, Cha-Min Tang, Sunggu Yang |
| Abstract |
Dendritic ion channels have been a subject of intense research in neuroscience because active ion channels in dendrites shape input signals. Ca(2+)-permeable channels including NMDA receptors (NMDARs) have been implicated in supralinear dendritic integration, and the IA conductance in sublinear integration. Despite their essential roles in dendritic integration, it has remained uncertain whether these conductance coordinate with, or counteract, each other in the process of dendritic integration. To address this question, experiments were designed in hippocampal CA1 neurons with a recent 3D digital holography system that has shown excellent performance for spatial photoactivation. The results demonstrated a role of IA as a key modulator for two distinct dendritic spikes, low- and high-threshold Ca(2+) spikes, through a preferential action of IA on Ca(2+)-permeable channel-mediated currents, over fast AMPAR-mediated currents. It is likely that the rapid kinetics of IA provides feed-forward inhibition to counteract the regenerative Ca(2+) channel-mediated dendritic excitability. This research reveals one dynamic ionic mechanism of dendritic integration, and may contribute to a new understanding of neuronal hyperexcitability embedded in several neural diseases such as epilepsy, fragile X syndrome and Alzheimer's disease. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 15% |
| Student > Ph. D. Student | 3 | 15% |
| Student > Master | 3 | 15% |
| Other | 2 | 10% |
| Researcher | 2 | 10% |
| Other | 3 | 15% |
| Unknown | 4 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 35% |
| Agricultural and Biological Sciences | 3 | 15% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Physics and Astronomy | 1 | 5% |
| Computer Science | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 5 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2016.
All research outputs
#14,830,048
of 22,835,198 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,396
of 4,249 outputs
Outputs of similar age
#216,428
of 389,038 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#58
of 101 outputs
Altmetric has tracked 22,835,198 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,249 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 389,038 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.