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Mendeley readers
Attention Score in Context
| Title |
Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, January 2016
|
| DOI | 10.3389/fncel.2015.00516 |
| Pubmed ID | |
| Authors |
Nicolas Doyon, Steven A. Prescott, Yves De Koninck |
| Abstract |
Disinhibition caused by Cl(-) dysregulation is implicated in several neurological disorders. This form of disinhibition, which stems primarily from impaired Cl(-) extrusion through the co-transporter KCC2, is typically identified by a depolarizing shift in GABA reversal potential (E GABA). Here we show, using computer simulations, that intracellular [Cl(-)] exhibits exaggerated fluctuations during transient Cl(-) loads and recovers more slowly to baseline when KCC2 level is even modestly reduced. Using information theory and signal detection theory, we show that increased Cl(-) lability and settling time degrade neural coding. Importantly, these deleterious effects manifest after less KCC2 reduction than needed to produce the gross changes in E GABA required for detection by most experiments, which assess KCC2 function under weak Cl(-) load conditions. By demonstrating the existence and functional consequences of "occult" Cl(-) dysregulation, these results suggest that modest KCC2 hypofunction plays a greater role in neurological disorders than previously believed. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 52 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 26% |
| Researcher | 9 | 17% |
| Student > Master | 8 | 15% |
| Student > Bachelor | 6 | 11% |
| Student > Doctoral Student | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 24 | 44% |
| Agricultural and Biological Sciences | 11 | 20% |
| Medicine and Dentistry | 5 | 9% |
| Mathematics | 1 | 2% |
| Computer Science | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 8 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2016.
All research outputs
#18,437,241
of 22,842,950 outputs
Outputs from Frontiers in Cellular Neuroscience
#3,259
of 4,251 outputs
Outputs of similar age
#286,818
of 396,346 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#77
of 109 outputs
Altmetric has tracked 22,842,950 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,251 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.