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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Reelin Proteolysis Affects Signaling Related to Normal Synapse Function and Neurodegeneration
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, March 2016
|
| DOI | 10.3389/fncel.2016.00075 |
| Pubmed ID | |
| Authors |
April L. Lussier, Edwin J. Weeber, G. William Rebeck |
| Abstract |
Reelin is a neurodevelopmental protein important in adult synaptic plasticity and learning and memory. Recent evidence points to the importance for Reelin proteolysis in normal signaling and in cognitive function. Support for the dysfunction of Reelin proteolysis in neurodegeneration and cognitive dysfunction comes from postmortem analysis of Alzheimer's diseases (AD) tissues including cerebral spinal fluid (CSF), showing that levels of Reelin fragments are altered in AD compared to control. Potential key proteases involved in Reelin proteolysis have recently been defined, identifying processes that could be altered in neurodegeneration. Introduction of full-length Reelin and its proteolytic fragments into several mouse models of neurodegeneration and neuropsychiatric disorders quickly promote learning and memory. These findings support a role for Reelin in learning and memory and suggest further understanding of these processes are important to harness the potential of this pathway in treating cognitive symptoms in neuropsychiatric and neurodegenerative diseases. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 25% |
| Switzerland | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 65 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 12 | 18% |
| Researcher | 9 | 13% |
| Student > Master | 9 | 13% |
| Student > Ph. D. Student | 8 | 12% |
| Student > Doctoral Student | 3 | 4% |
| Other | 11 | 16% |
| Unknown | 15 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 25% |
| Agricultural and Biological Sciences | 11 | 16% |
| Biochemistry, Genetics and Molecular Biology | 10 | 15% |
| Psychology | 5 | 7% |
| Medicine and Dentistry | 3 | 4% |
| Other | 6 | 9% |
| Unknown | 15 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2020.
All research outputs
#2,252,198
of 22,858,915 outputs
Outputs from Frontiers in Cellular Neuroscience
#339
of 4,254 outputs
Outputs of similar age
#39,081
of 300,926 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#6
of 93 outputs
Altmetric has tracked 22,858,915 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,254 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,926 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.