Title |
Failure of the Nemo Trial: Bumetanide Is a Promising Agent to Treat Many Brain Disorders but Not Newborn Seizures
|
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Published in |
Frontiers in Cellular Neuroscience, April 2016
|
DOI | 10.3389/fncel.2016.00090 |
Pubmed ID | |
Authors |
Yehezkel Ben-Ari, Philippe Damier, Eric Lemonnier |
Abstract |
The diuretic bumetanide failed to treat acute seizures due to hypoxic ischemic encephalopathy (HIE) in newborn babies and was associated with hearing loss (NEMO trial, Pressler et al., 2015). On the other hand, clinical and experimental observations suggest that the diuretic might provide novel therapy for many brain disorders including Autism Spectrum Disorders (ASD), schizophrenia, Rett syndrome, and Parkinson disease. Here, we discuss the differences between the pathophysiology of severe recurrent seizures in the neonates and neurological and psychiatric disorders stressing the uniqueness of severe seizures in newborn in comparison to other disorders. |
X Demographics
Geographical breakdown
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Canada | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 72 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 13 | 18% |
Student > Ph. D. Student | 9 | 13% |
Researcher | 8 | 11% |
Student > Doctoral Student | 5 | 7% |
Student > Bachelor | 5 | 7% |
Other | 15 | 21% |
Unknown | 17 | 24% |
Readers by discipline | Count | As % |
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Neuroscience | 25 | 35% |
Medicine and Dentistry | 11 | 15% |
Agricultural and Biological Sciences | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Psychology | 2 | 3% |
Other | 6 | 8% |
Unknown | 20 | 28% |