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Mendeley readers
Attention Score in Context
| Title |
Effects of an High-Fat Diet Enriched in Lard or in Fish Oil on the Hypothalamic Amp-Activated Protein Kinase and Inflammatory Mediators
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, June 2016
|
| DOI | 10.3389/fncel.2016.00150 |
| Pubmed ID | |
| Authors |
Emanuela Viggiano, Maria Pina Mollica, Lillà Lionetti, Gina Cavaliere, Giovanna Trinchese, Chiara De Filippo, Sergio Chieffi, Marcello Gaita, Antonio Barletta, Bruno De Luca, Marianna Crispino, Marcellino Monda |
| Abstract |
The high fat diet (HFD) rich in lard induces obesity, inflammation and oxidative stress, and the deregulation of hypothalamic nuclei plays an important role in this mechanism. One important factor involved in the food intake and inflammation is adenosine monophosphate-dependent kinase (AMPK), a serine/threonine kinase activated by phosphorylation. Omega (ω)3-polyunsaturated fatty acids (PUFA) are dietary compounds known to attenuate the obesity-related diseases, although the molecular mechanisms underlying their actions in the hypothalamus are not completely understood. We hypothesized that the beneficial effects of PUFA may be mediated by AMPK in the hypothalamus. To this aim, rats were fed a control diet (CD), or isocaloric HFD containing either fish oil (FD; rich in ω3-PUFA) or lard for 6 weeks, and the activation of AMPK, inflammatory state (IKKβ, TNF-α) and oxidative stress were analyzed in the hypothalamus. In addition, we also studied serum lipid profile, homeostatic model assessment (HOMA) index, and pro-inflammatory parameters. Our results showed, at the hypothalamic level of LD-fed rats, an increase of AMPK activation, inflammation and oxidative stress, while no modifications were detected in FD-fed animals compared to CD. In addition body weight gain, serum lipid profile, pro-inflammatory parameters and insulin resistance were reduced in FD animals compared to LD. In conclusion, our data indicate that the substitution of saturated by unsaturated fatty acids in the diet has beneficial effects on modulation of hypothalamic inflammation and function in obesity, underlying, at hypothalamic level, the interaction among insulin and/or leptin resistance, AMPK activation and hyperphagia. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 13% |
| Switzerland | 4 | 13% |
| Norway | 2 | 6% |
| United Kingdom | 2 | 6% |
| Canada | 2 | 6% |
| Ecuador | 1 | 3% |
| Mexico | 1 | 3% |
| France | 1 | 3% |
| Australia | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 13 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 23 | 72% |
| Scientists | 4 | 13% |
| Practitioners (doctors, other healthcare professionals) | 4 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 84 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 14% |
| Student > Doctoral Student | 11 | 13% |
| Student > Master | 10 | 12% |
| Researcher | 10 | 12% |
| Student > Bachelor | 7 | 8% |
| Other | 13 | 15% |
| Unknown | 22 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 18% |
| Agricultural and Biological Sciences | 14 | 16% |
| Biochemistry, Genetics and Molecular Biology | 10 | 12% |
| Neuroscience | 9 | 11% |
| Chemistry | 5 | 6% |
| Other | 13 | 15% |
| Unknown | 19 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 206. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#188,650
of 25,312,451 outputs
Outputs from Frontiers in Cellular Neuroscience
#19
of 4,685 outputs
Outputs of similar age
#3,639
of 351,356 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#3
of 76 outputs
Altmetric has tracked 25,312,451 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,685 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,356 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.