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Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function

Overview of attention for article published in Frontiers in Cellular Neuroscience, June 2016
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  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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Title
Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function
Published in
Frontiers in Cellular Neuroscience, June 2016
DOI 10.3389/fncel.2016.00157
Pubmed ID
Authors

Carla Garza-Lombó, María E. Gonsebatt

Abstract

The kinase mammalian target of rapamycin (mTOR) integrates signals triggered by energy, stress, oxygen levels, and growth factors. It regulates ribosome biogenesis, mRNA translation, nutrient metabolism, and autophagy. mTOR participates in various functions of the brain, such as synaptic plasticity, adult neurogenesis, memory, and learning. mTOR is present during early neural development and participates in axon and dendrite development, neuron differentiation, and gliogenesis, among other processes. Furthermore, mTOR has been shown to modulate lifespan in multiple organisms. This protein is an important energy sensor that is present throughout our lifetime its role must be precisely described in order to develop therapeutic strategies and prevent diseases of the central nervous system. The aim of this review is to present our current understanding of the functions of mTOR in neural development, the adult brain and aging.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 1 <1%
Unknown 100 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 20%
Researcher 13 13%
Student > Master 11 11%
Student > Bachelor 10 10%
Student > Postgraduate 5 5%
Other 21 21%
Unknown 21 21%
Readers by discipline Count As %
Neuroscience 21 21%
Agricultural and Biological Sciences 21 21%
Biochemistry, Genetics and Molecular Biology 16 16%
Medicine and Dentistry 9 9%
Immunology and Microbiology 2 2%
Other 12 12%
Unknown 20 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2016.
All research outputs
#13,239,298
of 22,877,793 outputs
Outputs from Frontiers in Cellular Neuroscience
#1,751
of 4,256 outputs
Outputs of similar age
#169,463
of 326,206 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#24
of 73 outputs
Altmetric has tracked 22,877,793 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,256 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,206 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.