Title |
Correlates of Post-Stroke Brain Plasticity, Relationship to Pathophysiological Settings and Implications for Human Proof-of-Concept Studies
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Published in |
Frontiers in Cellular Neuroscience, August 2016
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DOI | 10.3389/fncel.2016.00196 |
Pubmed ID | |
Authors |
Eduardo H. Sanchez-Mendoza, Dirk Matthias Hermann |
Abstract |
The promotion of neurological recovery by enhancing neuroplasticity has recently obtained strong attention in the stroke field. Experimental studies support the hypothesis that stroke recovery can be improved by therapeutic interventions that augment neuronal sprouting. However plasticity responses of neurons are highly complex, involving the growth and differentiation of axons, dendrites, dendritic spines and synapses, which depend on the pathophysiological setting and are tightly controlled by extracellular and intracellular signals. Thorough mechanistic insights are needed into how neuronal plasticity is influenced by plasticity-promoting therapies in order not to risk the success of future clinical proof-of-concept studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 17% |
Student > Doctoral Student | 6 | 14% |
Student > Ph. D. Student | 5 | 12% |
Student > Master | 4 | 10% |
Student > Postgraduate | 3 | 7% |
Other | 5 | 12% |
Unknown | 12 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 10 | 24% |
Medicine and Dentistry | 7 | 17% |
Agricultural and Biological Sciences | 2 | 5% |
Nursing and Health Professions | 2 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 5 | 12% |
Unknown | 15 | 36% |