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Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins

Overview of attention for article published in Frontiers in Cellular Neuroscience, August 2016
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Title
Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins
Published in
Frontiers in Cellular Neuroscience, August 2016
DOI 10.3389/fncel.2016.00199
Pubmed ID
Authors

Fernanda Ledda, Gustavo Paratcha

Abstract

Proper function of the nervous system critically relies on sophisticated neuronal networks interconnected in a highly specific pattern. The architecture of these connections arises from sequential developmental steps such as axonal growth and guidance, dendrite development, target determination, synapse formation and plasticity. Leucine-rich repeat (LRR) transmembrane proteins have been involved in cell-type specific signaling pathways that underlie these developmental processes. The members of this superfamily of proteins execute their functions acting as trans-synaptic cell adhesion molecules involved in target specificity and synapse formation or working in cis as cell-intrinsic modulators of neurotrophic factor receptor trafficking and signaling. In this review, we will focus on novel physiological mechanisms through which LRR proteins regulate neurotrophic factor receptor signaling, highlighting the importance of these modulatory events for proper axonal extension and guidance, tissue innervation and dendrite morphogenesis. Additionally, we discuss few examples linking this set of LRR proteins to neurodevelopmental and psychiatric disorders.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Researcher 4 12%
Student > Bachelor 3 9%
Student > Doctoral Student 3 9%
Professor > Associate Professor 2 6%
Other 5 15%
Unknown 9 26%
Readers by discipline Count As %
Neuroscience 7 21%
Medicine and Dentistry 5 15%
Biochemistry, Genetics and Molecular Biology 4 12%
Agricultural and Biological Sciences 4 12%
Immunology and Microbiology 1 3%
Other 2 6%
Unknown 11 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2016.
All research outputs
#18,467,278
of 22,882,389 outputs
Outputs from Frontiers in Cellular Neuroscience
#3,264
of 4,256 outputs
Outputs of similar age
#279,252
of 361,775 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#37
of 52 outputs
Altmetric has tracked 22,882,389 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,256 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,775 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.