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Mendeley readers
Attention Score in Context
| Title |
What Do We Really Know About 5-HT1A Receptor Signaling in Neuronal Cells?
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, November 2016
|
| DOI | 10.3389/fncel.2016.00272 |
| Pubmed ID | |
| Authors |
Paulina S. Rojas, Jenny L. Fiedler |
| Abstract |
Serotonin (5-HT) is a neurotransmitter that plays an important role in neuronal plasticity. Variations in the levels of 5-HT at the synaptic cleft, expression or dysfunction of 5-HT receptors may alter brain development and predispose to various mental diseases. Here, we review the transduction pathways described in various cell types transfected with recombinant 5-HT1A receptor (5-HT1AR), specially contrasting with those findings obtained in neuronal cells. The 5-HT1AR is detected in early stages of neural development and is located in the soma, dendrites and spines of hippocampal neurons. The 5-HT1AR differs from other 5-HT receptors because it is coupled to different pathways, depending on the targeted cell. The signaling pathway associated with this receptor is determined by Gα isoforms and some cascades involve βγ signaling. The activity of 5-HT1AR usually promotes a reduction in neuronal excitability and firing, provokes a variation in cAMP and Ca(2+), levels which may be linked to specific types of behavior and cognition. Furthermore, evidence indicates that 5-HT1AR induces neuritogesis and synapse formation, probably by modulation of the neuronal cytoskeleton through MAPK and phosphoinositide-3-kinase (PI3K)-Akt signaling pathways. Advances in understanding the actions of 5-HT1AR and its association with different signaling pathways in the central nervous system will reveal their pivotal role in health and disease. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 136 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 20% |
| Researcher | 18 | 13% |
| Student > Master | 14 | 10% |
| Student > Bachelor | 14 | 10% |
| Student > Doctoral Student | 12 | 9% |
| Other | 20 | 15% |
| Unknown | 32 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 35 | 26% |
| Agricultural and Biological Sciences | 14 | 10% |
| Biochemistry, Genetics and Molecular Biology | 13 | 9% |
| Medicine and Dentistry | 11 | 8% |
| Chemistry | 8 | 6% |
| Other | 20 | 15% |
| Unknown | 36 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2016.
All research outputs
#15,349,341
of 22,908,162 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,618
of 4,257 outputs
Outputs of similar age
#248,411
of 415,144 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#41
of 69 outputs
Altmetric has tracked 22,908,162 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,257 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 415,144 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.