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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Serotonin Regulates the Firing of Principal Cells of the Subiculum by Inhibiting a T-type Ca2+ Current
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, March 2017
|
| DOI | 10.3389/fncel.2017.00060 |
| Pubmed ID | |
| Authors |
Anders V. Petersen, Camilla S. Jensen, Valérie Crépel, Mathias Falkerslev, Jean-François Perrier |
| Abstract |
The subiculum is the main output of the hippocampal formation. A high proportion of its principal neurons fire action potentials in bursts triggered by the activation of low threshold calcium currents. This firing pattern promotes synaptic release and regulates spike-timing-dependent plasticity. The subiculum receives a high density of fibers originating from the raphe nuclei, suggesting that serotonin (5-HT) modulates subicular neurons. Here we investigated if and how 5-HT modulates the firing pattern of bursting neurons. By combining electrophysiological analysis with pharmacology, optogenetics and calcium imaging, we demonstrate that 5-HT2C receptors reduce bursting activity by inhibiting a low-threshold calcium current mediated by T-type Ca(2+) channels in principal cells of the subiculum. In addition, we show that the activation of this novel pathway decreases bursting activity and the occurrence of epileptiform discharges induced in in vitro models for temporal lobe epilepsy (TLE). |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 33% |
| Denmark | 2 | 13% |
| Japan | 1 | 7% |
| France | 1 | 7% |
| Ireland | 1 | 7% |
| Switzerland | 1 | 7% |
| Chile | 1 | 7% |
| Unknown | 3 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 80% |
| Scientists | 3 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 28% |
| Student > Bachelor | 9 | 19% |
| Researcher | 9 | 19% |
| Student > Master | 6 | 13% |
| Professor | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 7 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 15 | 32% |
| Agricultural and Biological Sciences | 6 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 9% |
| Medicine and Dentistry | 4 | 9% |
| Chemistry | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 12 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2017.
All research outputs
#3,924,742
of 24,286,850 outputs
Outputs from Frontiers in Cellular Neuroscience
#832
of 4,512 outputs
Outputs of similar age
#66,688
of 311,827 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#24
of 105 outputs
Altmetric has tracked 24,286,850 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,512 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,827 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.