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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, May 2017
|
| DOI | 10.3389/fncel.2017.00140 |
| Pubmed ID | |
| Authors |
Caroline Fasano, Jill Rocchetti, Katarzyna Pietrajtis, Johannes-Friedrich Zander, Frédéric Manseau, Diana Y. Sakae, Maya Marcus-Sells, Lauriane Ramet, Lydie J. Morel, Damien Carrel, Sylvie Dumas, Susanne Bolte, Véronique Bernard, Erika Vigneault, Romain Goutagny, Gudrun Ahnert-Hilger, Bruno Giros, Stéphanie Daumas, Sylvain Williams, Salah El Mestikawy |
| Abstract |
Hippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses the GABA/glycine vesicular transporters (VIAAT) and the atypical type III vesicular glutamate transporter (VGLUT3); therefore, these cells have the ability to signal with both GABA and glutamate. GABAergic transmission by basket cells has been extensively characterized but nothing is known about the functional implications of VGLUT3-dependent glutamate released by these cells. Here, using VGLUT3-null mice we observed that the loss of VGLUT3 results in a metaplastic shift in synaptic plasticity at Shaeffer's collaterals - CA1 synapses and an altered theta oscillation. These changes were paralleled by the loss of a VGLUT3-dependent inhibition of GABAergic current in CA1 pyramidal layer. Therefore presynaptic type III metabotropic could be activated by glutamate released from VGLUT3-positive interneurons. This putative presynaptic heterologous feedback mechanism inhibits local GABAergic tone and regulates the hippocampal neuronal network. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 72 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 28% |
| Researcher | 12 | 17% |
| Student > Bachelor | 10 | 14% |
| Student > Master | 9 | 13% |
| Professor > Associate Professor | 5 | 7% |
| Other | 4 | 6% |
| Unknown | 12 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 36 | 50% |
| Agricultural and Biological Sciences | 7 | 10% |
| Medicine and Dentistry | 4 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Arts and Humanities | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 19 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2017.
All research outputs
#7,787,528
of 23,652,325 outputs
Outputs from Frontiers in Cellular Neuroscience
#1,498
of 4,388 outputs
Outputs of similar age
#120,469
of 311,600 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#27
of 95 outputs
Altmetric has tracked 23,652,325 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,388 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,600 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.