Title |
Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation
|
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Published in |
Frontiers in Cellular Neuroscience, September 2017
|
DOI | 10.3389/fncel.2017.00281 |
Pubmed ID | |
Authors |
Li Zhou, Di Chen, Xu-Ming Huang, Fei Long, Hua Cai, Wen-Xia Yao, Zhong-Cheng Chen, Zhi-Jian Liao, Zhe-Zhi Deng, Sha Tan, Yi-Long Shan, Wei Cai, Yu-Ge Wang, Ri-Hong Yang, Nan Jiang, Tao Peng, Ming-Fan Hong, Zheng-Qi Lu |
Abstract |
β-Amyloid protein (Aβ) is thought to cause neuronal loss in Alzheimer's disease (AD). Aβ treatment promotes the re-activation of a mitotic cycle and induces rapid apoptotic death of neurons. However, the signaling pathways mediating cell-cycle activation during neuron apoptosis have not been determined. We find that Wnt5a acts as a mediator of cortical neuron survival, and Aβ42 promotes cortical neuron apoptosis by downregulating the expression of Wnt5a. Cell-cycle activation is mediated by the reduced inhibitory effect of Wnt5a in Aβ42 treated cortical neurons. Furthermore, Wnt5a signals through the non-canonical Wnt/Ca(2+) pathway to suppress cyclin D1 expression and negatively regulate neuronal cell-cycle activation in a cell-autonomous manner. Together, aberrant downregulation of Wnt5a signaling is a crucial step during Aβ42 induced cortical neuron apoptosis and might contribute to AD-related neurodegeneration. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 16% |
Student > Bachelor | 5 | 14% |
Researcher | 5 | 14% |
Student > Ph. D. Student | 5 | 14% |
Other | 3 | 8% |
Other | 5 | 14% |
Unknown | 8 | 22% |
Readers by discipline | Count | As % |
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Neuroscience | 9 | 24% |
Biochemistry, Genetics and Molecular Biology | 8 | 22% |
Agricultural and Biological Sciences | 5 | 14% |
Psychology | 2 | 5% |
Immunology and Microbiology | 1 | 3% |
Other | 2 | 5% |
Unknown | 10 | 27% |