Title |
Targeting WNT Signaling for Multifaceted Glioblastoma Therapy
|
---|---|
Published in |
Frontiers in Cellular Neuroscience, October 2017
|
DOI | 10.3389/fncel.2017.00318 |
Pubmed ID | |
Authors |
Matthew McCord, Yoh-suke Mukouyama, Mark R. Gilbert, Sadhana Jackson |
Abstract |
The WNT signaling pathway has been of great interest to developmental biologists for decades and has more recently become a central topic for study in cancer biology. It is vital for cell growth and regulation of embryogenesis in many organ systems, particularly the CNS and its associated vasculature. We summarize the role of WNT in CNS development and describe how WNT signaling makes key contributions to malignant glioma stemness, invasiveness, therapeutic resistance, and angiogenesis. The role of WNT in these mechanisms, along with creation and maintainance of the blood-brain barrier (BBB), points to the potential of WNT as a multi-faceted target in malignant glioma therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 17% |
Portugal | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 129 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 22 | 17% |
Student > Ph. D. Student | 20 | 16% |
Student > Master | 14 | 11% |
Researcher | 11 | 9% |
Unspecified | 6 | 5% |
Other | 17 | 13% |
Unknown | 39 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 39 | 30% |
Agricultural and Biological Sciences | 14 | 11% |
Medicine and Dentistry | 10 | 8% |
Unspecified | 6 | 5% |
Engineering | 4 | 3% |
Other | 15 | 12% |
Unknown | 41 | 32% |